A Role of Remote Organs Effect in Acute Kidney Injury Outcome

Dépret, François; Prudhomme, Mathilde; Legrand, Matthieu

doi:10.1159/000476077

Cited by 28 publications

(21 citation statements)

References 39 publications

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“…[56][57][58][59][60] These observational studies are supported by experimental studies of AKI that provide plausible biological mechanisms for clinically relevant outcomes. [61][62][63][64] In a population that has developed CIN, there is a debate of whether this is associated with a clinically relevant longer-term adverse outcome. Several studies have demonstrated increased in-hospital and longterm mortality, CKD progression, and kidney failure in patients who developed AKI following contrast angiography, compared with those without AKI following coronary angiography.…”

Section: Cect Studies Of Cin With Nonrandomized Control Groupsmentioning

confidence: 99%

The Controversy of Contrast-Induced Nephropathy With Intravenous Contrast: What Is the Risk?

Rudnick

Leonberg‐Yoo

Litt

et al. 2020

American Journal of Kidney Diseases

131

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Section: Cect Studies Of Cin With Nonrandomized Control Groupsmentioning

confidence: 99%

The Controversy of Contrast-Induced Nephropathy With Intravenous Contrast: What Is the Risk?

Rudnick

Leonberg‐Yoo

Litt

et al. 2020

American Journal of Kidney Diseases

131

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“…The presence of a multi-scale network of transporters, together with possible compensatory up-regulation between transporters at the renal level [130], could have repercussions in normal physiology and pathophysiology of the transplanted organ and of the whole organism [61]. In this sense, a frequent consequence of reperfusion after localized tissue ischemia is injury to other organ systems, so-called distant or remote organ injury (ROI) [131][132][133], including hepatic changes after renal IR injury [134,135].…”

Section: Alteration Of the Graft Itselfmentioning

confidence: 99%

Effects of Ischemia-Reperfusion on Tubular Cell Membrane Transporters and Consequences in Kidney Transplantation

Faucher

Alarcan

Marquet

et al. 2020

JCM

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Ischemia-reperfusion (IR)-induced acute kidney injury (IRI) is an inevitable event in kidney transplantation. It is a complex pathophysiological process associated with numerous structural and metabolic changes that have a profound influence on the early and the late function of the transplanted kidney. Proximal tubular cells are particularly sensitive to IRI. These cells are involved in renal and whole-body homeostasis, detoxification processes and drugs elimination by a transporter-dependent, transcellular transport system involving Solute Carriers (SLCs) and ATP Binding Cassettes (ABCs) transporters. Numerous studies conducted mainly in animal models suggested that IRI causes decreased expression and activity of some major tubular transporters. This could favor uremic toxins accumulation and renal metabolic alterations or impact the pharmacokinetic/toxicity of drugs used in transplantation. It is of particular importance to understand the underlying mechanisms and effects of IR on tubular transporters in order to improve the mechanistic understanding of IRI pathophysiology, identify biomarkers of graft function or promote the design and development of novel and effective therapies. Modulation of transporters’ activity could thus be a new therapeutic opportunity to attenuate kidney injury during IR.

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“…The hypothesis of distant organ injury (lung, heart, brain, liver, etc.) has emerged over the last decade and may demonstrate the reason for the potential negative influence of AKI on outcome [53][54][55] . High mortality rate during AKI is largely due to this multiple organ dysfunction.…”

Section: Remote Organ Injury Following Renal I/r Injurymentioning

confidence: 99%

Most Important Cellular Changes Involved in Renal Ischemia Reperfusion Injury and the Consequent Impact on Selected Remote Organs

Khalifa

Ghoneim²

2018

UJPR

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Because of the high rate of baseline oxygen use by renal cells, kidney is highly influenced by obstruction of arterial blood inflow and subsequent shortage of the received oxygen, this condition is known as Ischemic injury. There are many clinical settings associated with unavoidable ischemic state such as kidney transplantation, partial nephrectomy or suprarenal procedures of the aorta. During ischemia many cellular changes occur including vascular congestion and adhesion of inflammatory cells to the endothelium with subsequent infiltration into the kidney tissue. Following ischemia, a phase known as Reperfusion begins and involves a return of blood and oxygen supply to micro vessels. Reperfusion was expected to restore the damage occurred during the ischemic phase, paradoxically, reperfusion leads to more congestion, red cells trapping and excessive generation of reactive oxygen species (ROS), which can oxidatively modify significantly every type of biomolecule, thereby inducing cell dysfunction and induce reperfusion injury. Ischemia reperfusion injury (IRI) is also related to a phenomenon called Remote Organ Injury (ROI) in which the damaging effect induced by I/R is not only restricted to the tissue that undergoing the initial ischemia but also it leads to injury to remote organs such as the liver, lung, gut. ROI usually occurs by the same mechanisms seen in the local injury induced by I/R including the generation of ROS, leukocytes, and inflammatory mediators (e.g; TNF-α). These substances are directly released from the primary injured tissue or indirectly from activated leukocytes or other inflammatory cells causing organ dysfunctions in distant organs.

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A Role of Remote Organs Effect in Acute Kidney Injury Outcome

Cited by 28 publications

References 39 publications

The Controversy of Contrast-Induced Nephropathy With Intravenous Contrast: What Is the Risk?

The Controversy of Contrast-Induced Nephropathy With Intravenous Contrast: What Is the Risk?

Effects of Ischemia-Reperfusion on Tubular Cell Membrane Transporters and Consequences in Kidney Transplantation

Most Important Cellular Changes Involved in Renal Ischemia Reperfusion Injury and the Consequent Impact on Selected Remote Organs

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