A Role of Sodium-Glucose Co-Transporter 2 in Cardiorenal Anemia Iron Deficiency Syndrome

Sano, Motoaki

doi:10.3390/ijms24065983

Cited by 8 publications

(5 citation statements)

References 77 publications

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“… 46–48 Cluster #7 focused on the involvement of Sodium-Glucose Co-Transporter 2 (SGLT2) in HF during energy metabolism regulation, hemodynamics, erythropoiesis, iron bioavailability and inflammatory set points. 49 The clinical findings are inspiring, and empagliflozin, by simply inhibiting SGLT2 expressed in renal tubular epithelial cells, not only effectively controls blood glucose levels, but also improves the prognosis of HF. 50 , 51 SGLT2 inhibitor, one of the hotspots in the field of HF, has recently been proven to increase hemoglobin levels, 52 which reinforces its position in the treatment of anemia in HF.…”

Section: Discussionmentioning

confidence: 99%

Anemia in Heart Failure: A Perspective from 20-Year Bibliometric Analysis

Yang,

Dong,

Lyu

et al. 2024

IJGM

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Background & Objective Anemia in patients with heart failure (HF) is a growing concern. However, there has no bibliometric analysis in this area up to now. The aim of this study is to explore the status and trends in the field of anemia in HF through the bibliometric analysis, and to provide an outlook on future research. Methods We retrieved publications from the Web of Science Core Collection database, and the following data analysis and visualization tools were utilized to perform data processing, statistical computing and graphics generation: VOSviewer (v.1.6.18), CiteSpace (v.6.2 R5), Scimago Graphica (v.1.0.36), Biblimatrix and Microsoft Excel. Results We identified a total of 3490 publications from 2004 to 2023. The publications in the field of anemia in HF are growing steadily. The United States, the United Kingdom, and Italy were the leading countries in this area. Stefan D Anker, as the most influential author, held the most total citations and publications. Harvard University was the most productive institution in this area. The European Journal of Heart Failure had published the most papers. Through the analysis of co-citations, 14 major clusters based on cluster labels were identified. Keyword analysis showed that mortality, outcome, prevalence, and risk were the most frequent keywords, and the potential research hotspots in the future will be intravenous iron and iron deficiency. Conclusion This study provides a comprehensive analysis of countries, authors, institutions, journals, co-cited references, and keywords in the field of anemia in HF through bibliometric analysis and data visualization. The status, hotspots and future trends in this field offer a reference for in-depth research. Further studies are necessary in the future to broaden the spectrum of research in this field, to evaluate comprehensive approaches to treating anemia in patients with HF, and to find rational targets for the management of anemia.

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Section: Discussionmentioning

confidence: 99%

Anemia in Heart Failure: A Perspective from 20-Year Bibliometric Analysis

Yang,

Dong,

Lyu

et al. 2024

IJGM

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“…Research indicated that the incidence and prevalence of diabetic patients were often related to erythropoietin deficiency caused by diabetic kidney damage [51]. The interaction of heart failure, renal dysfunction, anemia, and iron deficiency form a vicious cycle and diabetes further accelerates this vicious cycle [52]. Therefore, diabetic patients might be more likely to suffer from low hemoglobin symptoms.…”

Section: Discussionmentioning

confidence: 99%

The Association of Malnutrition and Health-Related Factors among 474,467 Older Community-Dwellers: A Population-Based Data Mining Study in Guangzhou, China

Lin,

Xiao,

Fang

et al. 2024

Nutrients

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Background: This study aimed to examine the prevalence and associated factors of malnutrition in older community-dwellers and explore the interaction between associated factors. Methods: A total of 474,467 older community-dwellers aged 65 or above were selected in Guangzhou, China. We used a two-step methodology to detect the associated factors of malnutrition and constructed logistic regression models to explore the influencing factors and interactive effects on three patterns of malnutrition. Results: The prevalence of malnutrition was 22.28%. Older adults with both hypertension and diabetes (RERI = 0.13), both meat or fish diet and hypertension (RERI = 0.79), and both meat or fish diet and diabetes (RERI = 0.81) had positive additive interaction effects on the risk of obesity, whereas those on a vegetarian diet with hypertension (RERI = −0.25) or diabetes (RERI = −0.19) had negative additive interaction effects. Moreover, the interactions of physical activity with a meat or fish diet (RERI = −0.84) or dyslipidemia (RERI = −0.09) could lower the risk of obesity. Conclusions: Malnutrition was influenced by different health factors, and there were interactions between these influencing factors. Pertinent dietary instruction should be given according to different nutritional status indexes and the prevalence of metabolic diseases to avoid the occurrences of malnutrition among older adults.

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“…The occurrence of iron deficiency/anemia in the development of all the diseases presented in the graphical abstract is at best noticed, although it might further help to clarify more fundamental mechanisms involved in disease progression. Recognizing a significant drop in hemoglobin as a sign of local glucose deprivation should start a clinical search for the underlying causes in order to prevent a vicious cycle where different diseases, such as insulin resistance and iron deficiency, affect each other (graphical abstract; [ 229 ]). Nutrition or the precautionary intake of phytochemicals with their anti-inflammatory effect might also help to improve cellular glucose import ( Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

Why Is Iron Deficiency/Anemia Linked to Alzheimer’s Disease and Its Comorbidities, and How Is It Prevented?

Fehsel

2023

Biomedicines

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Impaired iron metabolism has been increasingly observed in many diseases, but a deeper, mechanistic understanding of the cellular impact of altered iron metabolism is still lacking. In addition, deficits in neuronal energy metabolism due to reduced glucose import were described for Alzheimer’s disease (AD) and its comorbidities like obesity, depression, cardiovascular disease, and type 2 diabetes mellitus. The aim of this review is to present the molecular link between both observations. Insufficient cellular glucose uptake triggers increased ferritin expression, leading to depletion of the cellular free iron pool and stabilization of the hypoxia-induced factor (HIF) 1α. This transcription factor induces the expression of the glucose transporters (Glut) 1 and 3 and shifts the cellular metabolism towards glycolysis. If this first line of defense is not adequate for sufficient glucose supply, further reduction of the intracellular iron pool affects the enzymes of the mitochondrial electron transport chain and activates the AMP-activated kinase (AMPK). This enzyme triggers the translocation of Glut4 to the plasma membrane as well as the autophagic recycling of cell components in order to mobilize energy resources. Moreover, AMPK activates the autophagic process of ferritinophagy, which provides free iron urgently needed as a cofactor for the synthesis of heme- and iron–sulfur proteins. Excessive activation of this pathway ends in ferroptosis, a special iron-dependent form of cell death, while hampered AMPK activation steadily reduces the iron pools, leading to hypoferremia with iron sequestration in the spleen and liver. Long-lasting iron depletion affects erythropoiesis and results in anemia of chronic disease, a common condition in patients with AD and its comorbidities. Instead of iron supplementation, drugs, diet, or phytochemicals that improve energy supply and cellular glucose uptake should be administered to counteract hypoferremia and anemia of chronic disease.

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A Role of Sodium-Glucose Co-Transporter 2 in Cardiorenal Anemia Iron Deficiency Syndrome

Cited by 8 publications

References 77 publications

Anemia in Heart Failure: A Perspective from 20-Year Bibliometric Analysis

Anemia in Heart Failure: A Perspective from 20-Year Bibliometric Analysis

The Association of Malnutrition and Health-Related Factors among 474,467 Older Community-Dwellers: A Population-Based Data Mining Study in Guangzhou, China

Why Is Iron Deficiency/Anemia Linked to Alzheimer’s Disease and Its Comorbidities, and How Is It Prevented?

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