2005
DOI: 10.1016/j.cellsig.2005.03.005
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A role of the protein Cbl in FGF-2-induced angiogenesis in murine brain endothelial cells

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Cited by 4 publications
(4 citation statements)
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“…hPLD activity is stimulated in vitro and in vivo by protein kinase C and small GTPases, such as Arf and Cdc42. 2731 Stimulation of PldA activity in vitro was not observed for these small GTPases or protein kinase C (data not shown).…”
Section: Resultsmentioning
confidence: 92%
“…hPLD activity is stimulated in vitro and in vivo by protein kinase C and small GTPases, such as Arf and Cdc42. 2731 Stimulation of PldA activity in vitro was not observed for these small GTPases or protein kinase C (data not shown).…”
Section: Resultsmentioning
confidence: 92%
“…VEGFR2 is the most important VEGF receptor in tumor angiogenesis, and mediates the majority of VEGF effects. The results from other labs have shown that FGFR1 were expressed for angiogenesis in the aortic endothelial cells upon FGF-2 stimulation 19,20. Therefore, we focused our studies on VEGFR2 and FGFR1.…”
Section: Resultsmentioning
confidence: 99%
“…The results from other labs have shown that FGFR1 were expressed for angiogenesis in the aortic endothelial cells upon FGF-2 stimulation. 19,20 Therefore, we focused our studies on VEGFR2 and FGFR1. We co-cultured the irradiated MCF-7 cells with the non-irradiated BAEC for 16 h. Co-culture of irradiated MCF-7 cells with 2 Gy exposures could significantly increase the expression levels of VEGFR2 and FGFR1 in BAEC by 2.9 ± 0.9-fold and 3.8 ± 0.3-fold separately.…”
Section: Resultsmentioning
confidence: 99%
“…Similarly, trafficking of VEGFR (VEGF receptor) 1 and 2 are thought to involve a complex that contains c-Cbl [36,37]. In contrast, trafficking of the FGF receptor does not seem to require c-Cbl, but uses c-Cbl as a signalling adaptor [38]. Collectively, these results suggest that the role of c-Cbl in angiogenesis may very well depend on the signalling pathway initiating the angiogenic response, and that c-Cbl-targeted therapies will need to take this into consideration.…”
Section: Discussionmentioning
confidence: 99%