A route to access imidazol[1,5-a]indole-1,3-diones and pyrrolo[1,2-c]imidazole-1,3-diones

Abstract

A simple and practical method for synthesizing imidazol[1,5-a]indoles and pyrrolo[1,2-c]imidazoles has been developed. The present method uses microwave conditions and is free from the need for work-up and column chromatography.

Contributing to Biochemistry and Optoelectronics: Pyrrolo[1′,2′:2,3]imidazo[1,5-a]indoles and Cyclohepta[4,5]pyrrolo[1,2-c]pyrrolo[1,2-a]imidazoles via [3+2] Annulation of Acylethynylcycloalka[b]pyrroles with Δ1-Pyrrolines

“…The known approaches to the synthesis of pyrrolo[1,2- c ]imidazoles include the intermolecular cyclocondensation of pyrrole, isocyanate and phosgene or thiophosgene [ 16 , 17 ], benzotriazol-1-yl(1 H -pyrrol-2-yl)methanone with ketone, isocyanate or isothiocyanate [ 18 ]; pyrrole-2-carboxylic acid, amine and carbonyl diimidazole [ 5 , 19 ], Rh(III)- and Pd(0)-catalyzed C2-H functionalization of pyrroles with alkynes, alkenes and diazo compounds [ 20 , 21 ]; post-Ugi cascade reaction [ 7 ]; and flash vacuum pyrolysis of imidazol-1-ylacrylates [ 22 ].…”