A route to high radioactivity3H-labelled PLA polymers

Santos, Isabelle Dos; Morgat, Jean‐Louis; Vert, Michel

doi:10.1002/(sici)1097-0126(199904)48:4<283::aid-pi123>3.0.co;2-v

Cited by 7 publications

(1 citation statement)

References 13 publications

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“…Hence the need for catalysts, such as palladium on charcoal, to direct ``hydrogenation'' to speci¢c ole¢nic sites, as in the preparation of tritiated progesterone derivatives 46 or substituted azidobenzamides 47 or the use of partially deactivated palladium 48 in the preparation of some tritiated oxylipins. Similar catalysts can also induce tritium/hydrogen exchange in polylactide polymers 49 and polyacrylic hydrogels. 50 An advance is the use of organoiridium compounds 51 as catalysts since they give predictable regioselectivity and high speci¢c activities.…”

Section: Tritiummentioning

confidence: 99%

27 Radiochemistry

Urch¹

2000

Annu. Rep. Prog. Chem., Sect. A

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Section: Tritiummentioning

confidence: 99%

27 Radiochemistry

Urch¹

2000

Annu. Rep. Prog. Chem., Sect. A

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Synthesis of ³H and fluorescence‐labelled poly (DL‐Lactic acid)

Ponsart

Coudane

Morgat

et al. 2001

Labelled Comp Radiopharmac

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SummaryThe novel polymer modification method based on the activation of an aliphatic polyester chain by using lithium diisopropylamide at low temperature to form a polycarbanion bearing nucleophilic sites in a position a to the carbonyl groups was applied to rac-poly (lactic acid), PLA 50 , to label this polymer with radioactive tritium atoms or with a fluorescent dye. Despite simultaneous partial chain degradation, radioactive PLA 50 and fluorescent PLA 50 with M n ¼ 14 000 g mol À1 , M w =M n ¼ 1:9 and M n ¼ 32 000 g molrespectively, were obtained. The specific activity of the final compound was 3.7 mCi g À1 that squared with 0.3% substitution reaction. The fluorescent polymer was substituted with 0.25% ratio. This work shows that the LDA activation method appears to have considerable potential.

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Degradable polymers in a living environment: where do you end up?

Vert

Santos

Ponsart

et al. 2002

Polymer International

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The resistance of synthetic polymers to the action of living systems is becoming more and more problematic in certain domains in which they are used for a limited period of time before becoming waste. It is exemplified in surgery, pharmacology, agriculture and in the environment too. In these domains, time‐resistant polymeric wastes are less and less acceptable. From this viewpoint, sutures, bone fracture fixation devices, mulch films and packagings are comparable. Basically they should be eliminated after use. Post‐use biorecycling is regarded as a possible solution to some of the problems raised by the management of these polymeric wastes, regardless of the domain of application. This contribution aims to present simple and versatile methods with a potential to investigate the fate, and especially the bioassimilation, of the degradation by‐products of degradable or bio‐degradable polymers in complex living media such as the human body, a compost or the outdoor environment. Two versatile methods are presented that have been developed to radio‐label degradable and biodegradable artificial aliphatic polyesters by substituting some protons by tritium atoms. It is also shown that weighing a population of starved earthworms, allowed to be in contact with degradable or biodegradable polymer, is a worthwhile method to demonstrate that degradation by‐products are bioassimilated.© 2002 Society of Chemical Industry

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A route to high radioactivity3H-labelled PLA polymers

Cited by 7 publications

References 13 publications

27 Radiochemistry

27 Radiochemistry

Synthesis of ³H and fluorescence‐labelled poly (DL‐Lactic acid)

Degradable polymers in a living environment: where do you end up?

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A route to high radioactivity3H-labelled PLA polymers

Cited by 7 publications

References 13 publications

27 Radiochemistry

27 Radiochemistry

Synthesis of 3H and fluorescence‐labelled poly (DL‐Lactic acid)

Degradable polymers in a living environment: where do you end up?

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Synthesis of ³H and fluorescence‐labelled poly (DL‐Lactic acid)