2017
DOI: 10.1021/acs.inorgchem.7b01037
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A Ruthenium(II) Complex as a Luminescent Probe for DNA Mismatches and Abasic Sites

Abstract: [Ru(bpy)2(BNIQ)]2+ (BNIQ = Benzo[c][1,7]naphthyridine-1-isoquinoline), which incorporates the sterically expansive BNIQ ligand, is a highly selective luminescent probe for DNA mismatches and abasic sites, possessing a 500-fold higher binding affinity toward these destabilized regions relative to well-matched base pairs. As a result of this higher binding affinity, the complex exhibits an enhanced steady-state emission in the presence of DNA duplexes containing a single base mismatch or abasic site compared to … Show more

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Cited by 47 publications
(37 citation statements)
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“…In this context, polyazaaromatic ruthenium(II) complexes represent ideal candidates to target genetic material such as G4s. By virtue of their optical properties, including a large Stokes shift, good photostability, high quantum yield, and long‐lived luminescence, they have been developed to probe different DNA sequences, such as mismatches, abasic sites, or G4s . More recently, two ruthenium(II) complexes, [Ru(phen) 2 (dph)] 2+ and [{Ru(phen) 2 } 2 (dph)] 4+ , based on the dph ligand (dph=dipyrazino[2,3‐ a :2′,3′‐ h ]phenazine), have been reported to show good selectivity towards G4s .…”
Section: Introductionsupporting
confidence: 86%
“…In this context, polyazaaromatic ruthenium(II) complexes represent ideal candidates to target genetic material such as G4s. By virtue of their optical properties, including a large Stokes shift, good photostability, high quantum yield, and long‐lived luminescence, they have been developed to probe different DNA sequences, such as mismatches, abasic sites, or G4s . More recently, two ruthenium(II) complexes, [Ru(phen) 2 (dph)] 2+ and [{Ru(phen) 2 } 2 (dph)] 4+ , based on the dph ligand (dph=dipyrazino[2,3‐ a :2′,3′‐ h ]phenazine), have been reported to show good selectivity towards G4s .…”
Section: Introductionsupporting
confidence: 86%
“…The complex [Ru(phen) 2 (dppz)] 2 + and its derivatives have been extensively studied since the originald emonstration of the DNA "light-switch" effect using [Ru(bpy) 2 (dppz)] 2 + (phen = phenanthroline, dppz = dipyridophenazine and bpy = bipyridine). [1] These complexes, andc lose derivatives,h ave been shown to be able to act as structure specific luminescent probes for mismatched DNA, [2,3] and for G-quadruplexes. [4,5] Relatedc omplexes can oxidiseg uanine upon irradiation, [6][7][8][9] explicitly directing DNA damage.…”
Section: Introductionmentioning
confidence: 99%
“…In this context,p olyazaaromatic ruthenium(II) complexes represent ideal candidates to target geneticmaterialsuch as G4s. By virtue of their optical properties, including al arge Stokes shift, good photostability,h igh quantum yield, and long-lived luminescence, they have been developed to probe differentD NA sequences, [38] such as mismatches, [39] abasic sites, [40] or G4s. [32] More recently,t wo ruthenium(II) complexes, [Ru(phen) 2 (dph)] 2 + and [{Ru(phen) 2 } 2 (dph)] 4 + ,b ased on the dph ligand (dph = dipyrazino[2,3-a:2',3'-h]phenazine), have been reported to show good selectivity towards G4s.…”
mentioning
confidence: 99%