A Safe Method of Retrograde Passage of Fogarty Embolectomy Catheter Through Difficult Iliac Arteries

Haldipur, Nandan; Tan, Patrick; Katory, Mark; Singh, Sarguni

doi:10.1053/ejvs.2002.1627

Cited by 2 publications

(2 citation statements)

References 1 publication

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“…The balloon-induced SCI strategy was chosen over other induction techniques because it is a straightforward procedure that causes no damage to the surrounding tissues, the dosage response depends on balloon volume, and the degree of injury occurs in dogs [ 38 ], in contrast to the previous Purdy’s models [ 39 , 40 ]. Embolectomy catheters were selected because they are stiffer and less irritating than other Forgaty catheters [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Selective Calpain Inhibition Improves Functional and Histopathological Outcomes in a Canine Spinal Cord Injury Model

Metwally

Al-Abbadi

Hashem

et al. 2022

IJMS

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Calpain activation has been implicated in various pathologies, including neurodegeneration. Thus, calpain inhibition could effectively prevent spinal cord injury (SCI) associated with neurodegeneration. In the current study, a dog SCI model was used to evaluate the therapeutic potential of a selective calpain inhibitor (PD150606) in combination with methylprednisolone sodium succinate (MPSS) as an anti-inflammatory drug. SCI was experimentally induced in sixteen mongrel dogs through an epidural balloon compression technique. The dogs were allocated randomly into four groups: control, MPSS, PD150606, and MPSS+PD150606. Clinical evaluation, serum biochemical, somatosensory evoked potentials, histopathological, and immunoblotting analyses were performed to assess treated dogs during the study. The current findings revealed that the combined administration of MPSS+PD150606 demonstrated considerably lower neuronal loss and microglial cell infiltration than the other groups, with a significant improvement in the locomotor score. The increased levels of inflammatory markers (GFAP and CD11) and calcium-binding proteins (Iba1 and S100) were significantly reduced in the combination group and to a lesser extent in MPSS or PD150606 treatment alone. Interestingly, the combined treatment effectively inhibited the calcium-induced cleavage of p35, limited cdk5 activation, and inhibited tau phosphorylation. These results suggest that early MPSS+PD150606 therapy after acute SCI may prevent subsequent neurodegeneration via calpain inhibition.

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Section: Discussionmentioning

confidence: 99%

Selective Calpain Inhibition Improves Functional and Histopathological Outcomes in a Canine Spinal Cord Injury Model

Metwally

Al-Abbadi

Hashem

et al. 2022

IJMS

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“…Compared to the study by Fukuda, our method of drilling a hemilaminectomy hole for insertion of a balloon catheter provided easy exposure of the spinal cord with no risk of hemorrhage in a relatively short time (30 min to 1 h). Embolectomy catheters used in this study, commonly used as arterial catheters, were more rigid and less irritable than other forgaty catheters [5]. The catheter used in the present study also had the advantage of being detectable in fluoroscopy without contrast.…”

Section: Discussionmentioning

confidence: 90%

Establishment of a canine spinal cord injury model induced by epidural balloon compression

et al. 2007

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A model that provides reproducible, submaximal yet sufficient spinal cord injury is needed to allow experiments leading to development of therapeutic techniques and prediction of clinical outcome to be conducted. This study describes an experimental model for spinal cord injury that uses three different volumes of balloon inflation and durations of compression to create a controlled gradation outcome in adult dogs. Twenty-seven mongrel dogs were used for this study. A 3-french embolectomy catheter was inserted into the epidural space through a left hemilaminectomy hole at the L4 vertebral arch. Balloons were then inflated with 50, 100, or 150 µl of a contrast agent at the L1 level for 6, 12, or 24 h and spinal canal occlusion (SCO) measured using computed tomography. Olby score was used to evaluate the extent of spinal cord injury and a histopathologic examination was conducted 1 week after surgery. The SCO of the 50, 100, and 150 µl inflations was 22-46%, 51-70%, and 75-89%, respectively (p < 0.05). Olby scores were diminished significantly by a combination of the level of SCO and duration of inflation in all groups. Olby scores in the groups of 150 µl-12 h, 150 µl-24 h, and 100 µl-24 h were 0.5, 0, and 1.7, respectively. Based on these results, a SCO > 50% for 24 h, and > 75% for 12 h induces paraplegia up to a week after spinal cord injury.

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A Safe Method of Retrograde Passage of Fogarty Embolectomy Catheter Through Difficult Iliac Arteries

Cited by 2 publications

References 1 publication

Selective Calpain Inhibition Improves Functional and Histopathological Outcomes in a Canine Spinal Cord Injury Model

Selective Calpain Inhibition Improves Functional and Histopathological Outcomes in a Canine Spinal Cord Injury Model

Establishment of a canine spinal cord injury model induced by epidural balloon compression

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