A safer hypoglycemic agent for type 2 diabetes—Berberine organic acid salt

Li, Jing-wan; Yuan, Kun; Sui-cun, Shang; Guo, Ying

doi:10.1016/j.jff.2017.09.031

Cited by 17 publications

(17 citation statements)

References 53 publications

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“…Berberine is an isoquinoline alkaloid extracted from the rhizomes of Ranunculaceae coptis or Cortex phellodendri . A number of clinical studies have shown that berberine has a significant hypoglycemic effect in patients with T2D [13]. However, the oral bioavailability of berberine is low (0.68%), and about half of the dose is not absorbed by the intestines [14, 15].…”

Section: Introductionmentioning

confidence: 99%

“…However, the oral bioavailability of berberine is low (0.68%), and about half of the dose is not absorbed by the intestines [14, 15]. Studies have shown that berberine organic acids can reduce blood glucose and have the good effects of berberine hydrochloride [13]. Fumaric acid, an intermediate product of the tricarboxylic acid (TCA) or Krebs cycle, has been widely used in food, sustainable chemistry, and biomedical applications, and fumarate is often used in the treatment of chronic inflammatory skin diseases and autoimmune diseases [16–18].…”

Section: Introductionmentioning

confidence: 99%

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Hypoglycemic Mechanism of the Berberine Organic Acid Salt under the Synergistic Effect of Intestinal Flora and Oxidative Stress

Cui

Li³

et al. 2018

Oxidative Medicine and Cellular Longevity

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Both alterations to the intestinal microflora and chronic systemic inflammation predispose towards type 2 diabetes (T2D). Changes in the composition of the intestinal microflora are associated with glucose metabolism changes in rats with T2D. Here, we demonstrate that a berberine fumarate (BF) has a hypoglycemic effect by regulating the intestinal microflora and metabolism of diabetic rats. The T2D rats had disorders of glucose and lipid metabolism, an abnormal intestinal microflora, fewer butyrate-producing and probiotic-type bacteria, larger numbers of potentially pathogenic and sulfate-reducing bacteria, and tissue inflammation. Administration of berberine fumarate significantly ameliorated the metabolic disorder; increased the populations of Bacteroidetes, Clostridia, Lactobacillales, Prevotellaceae, and Alloprevotella; and reduced those of Bacteroidales, Lachnospiraceae, Rikenellaceae, and Desulfovibrio. In addition, it reduced inflammation, inhibiting the overexpression of TLR4 and p-JNK and increasing the expression of PI3K, GLUT2, and other proteins, which are closely related to oxidative stress, thereby promoting the metabolism of glucose.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hypoglycemic Mechanism of the Berberine Organic Acid Salt under the Synergistic Effect of Intestinal Flora and Oxidative Stress

Cui

Li³

et al. 2018

Oxidative Medicine and Cellular Longevity

Self Cite

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“…Similarly, gelucire44/14 was found to enhance the oral absorption of BBR and thus improve the antidiabetic efficacy of BBR (Sun J. et al, 2018). Berberine organic acids (BOAs) were found to be comparable to berberine hydrochloride (BH) in terms of hypoglycaemic effects, they were but superior with regard to safety from hyperchloraemia in T2DM rats (Li et al, 2017). Coptis chinensis (containing berberine) and BBR exerted similar effects when used for the treatment of T2MD rats, mainly via the stimulation of the pancreatic secretion of insulin (Jiang et al, 2017).…”

Section: In Vivo Activities Against Diabetes and Metabolic Diseasesmentioning

confidence: 99%

Phytopharmacology and Clinical Updates of Berberis Species Against Diabetes and Other Metabolic Diseases

et al. 2020

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“…Berberine (BER) is a natural alkaloid isoquinoline sequestered from different plants like Berberis vulgaris (Jiang, Li, & Li, ). BER is a strong base which is usually unstable when present in free form so it usually accompanied with chloride ion in the form of BER‐chloride (Bodiwala, Sabde, Mitra, Bhutani, & Singh, ; Li, Yuan, Shang, & Guo, ). BER acts as an anticancer (Liu et al, ), anti‐inflammatory (Liu et al, ; Vuddanda, Chakraborty, & Singh, ), anti‐leishmanial (Vuddanda et al, ; Zhang et al, ), and anti‐immunodeficiency virus in humans (Dong et al, ).…”

Section: Introductionmentioning

confidence: 99%

Berberine chloride ameliorated PI3K/Akt‐p/SIRT‐1/PTEN signaling pathway in insulin resistance syndrome induced in rats

et al. 2019

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The liver is the main organ involved in lipid metabolism process and it helps in drug detoxification. Insulin resistance is considered one of risk reasons which lead to several metabolic diseases. Currently, berberine (BER) occupies a huge challenge against multiple diseases with no toxic effect. The present work was aimed to identify, does BER-chloride has a poisonous influence on the liver? and investigating the outcome of BER-chloride on PI3K/Akt-p/SIRT-1/PTEN pathway during insulin resistance syndrome. The insulin resistance model was achieved in experimental female rats via high-fat diet (HFD). Glucose, insulin, lipid profiles, and hepatic oxidative stress parameters were assessed. PI3K, AKt-p, SIRT-1, and PTEN levels in hepatic tissue were determined at genome and protein levels. Further adiponectin concentration was performed in serum, hepatic, and white adipose tissues. Molecular study of fold alteration in insulin, insulin receptor, and retinol binding protein-4 (RBP4) in liver was done. Practical applicationsObesity syndrome causes multiple obstacles in modern years. The current results revealed elevation the body weight of rats, plasma glucose, homeostatic model assessment, glycated hemoglobin, insulin, and lipid profiles concentrations in a group of rats, which nourished HFD for 8 weeks and this rise, was diminished after 2 weeks from BER-chloride administration. Further, BER-chloride improved transaminases enzymes, pro-oxidant, and antioxidant defense system, PI3K, AKt-p, SIRT-1, and PTEN in the liver, with downregulation of hepatic RBP4. Hence, these data provide a crucial message that BER-chloride enhanced both hepatic function and insulin signaling pathways that might be of therapeutic importance to insulin resistance with no harmful effect on the liver. BER-chloride is predicted to be a drug of choice for obesity complications cure. K E Y W O R D Sberberine chloride, hepatotoxicity, insulin receptor, liver

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A safer hypoglycemic agent for type 2 diabetes—Berberine organic acid salt

Cited by 17 publications

References 53 publications

Hypoglycemic Mechanism of the Berberine Organic Acid Salt under the Synergistic Effect of Intestinal Flora and Oxidative Stress

Hypoglycemic Mechanism of the Berberine Organic Acid Salt under the Synergistic Effect of Intestinal Flora and Oxidative Stress

Phytopharmacology and Clinical Updates of Berberis Species Against Diabetes and Other Metabolic Diseases

Berberine chloride ameliorated PI3K/Akt‐p/SIRT‐1/PTEN signaling pathway in insulin resistance syndrome induced in rats

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