A saliva substitute for use by xerostomic patients undergoing radiotherapy to the head and neck

Shannon, Ira L.; McCrary, B.R.; Starcke, Edgar N.

doi:10.1016/0030-4220(77)90373-5

Cited by 73 publications

(30 citation statements)

References 10 publications

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“…During the course of radiotherapy of pa tients with head and neck tumours, the sali vary glands, which are included in the field of irradiation, are usually damaged [1], This destruction is known to result in reduction of salivation, which secondarily causes dry mouth, sialoadenitis, mucositis, trismus, and dental caries [2][3][4][5], It has been recognized that ionizing irra diation affects the major salivary glands dif ferently, with the parotid gland being the most radiosensitive [6][7][8][9]. In the majority of animals, the three pairs of salivary glands have different histological classification: (1) the parotid gland is purely serous; (2) the submaxillary gland is mixed sero-mucous; (3) the sublingual gland is purely mucous [10].…”

Section: Introductionmentioning

confidence: 99%

Alpha-Adrenergic Stimulation and Radiosensitivity on the Rat Submaxillary Gland

Norberg

Forsberg²

1987

ORL

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The submaxillary glands were exposed to fractionated irradiation comparable to 50 Gy in clinical practice and a single fraction of 50 Gy. Half the number of rats were given cyclocytidine, an alpha-adrenergic agonist which depletes the serous cell granules before irradiation was embarked upon. Our results show that irradiation causes a significant, irreversible destruction of serous cells. With cyclocytidine pretreatment, the radiodamage was diminished and this drug is suggested to act as a radioprotector, depleting secretory heavy metal granules, and thus preventing radiodamage in the submaxillary salivary glands.

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Section: Introductionmentioning

confidence: 99%

Alpha-Adrenergic Stimulation and Radiosensitivity on the Rat Submaxillary Gland

Norberg

Forsberg²

1987

ORL

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“…To date, many therapeutic agents including saliva substitutes [26], intensity-modulated radiotherapy [27,28], pilocarpine [29,30,31,32], acupuncture [33,34], and amifostine [35,36] had been available to alleviate radiation-induced xerostomia, but they rarely had curable effects or were even controversial regarding the safety of their use. So, the best method to treat postradiation xerostomia would be to choose preventive measures.…”

Section: Introductionmentioning

confidence: 99%

Submandibular Gland Transfer for the Prevention of Postradiation Xerostomia in Patients with Head and Neck Cancer: A Systematic Review and Meta-Analysis

Wu¹,

Weng²,

Li³

et al. 2015

ORL

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Background: Submandibular gland transfer has been widely used to prevent postradiation xerostomia in head-and-neck cancers. However, there are still some controversies. Methods: Six databases were searched, data extraction was performed and the risk of bias was assessed by 2 reviewers independently. The meta-analysis was performed using Review Manager, version 5.2. Results: A total of 7 trials (12 articles) and 369 participants were included. Conclusions: The present clinical evidence suggests that submandibular gland transfer might be highly effective to prevent postradiation xerostomia in head-and-neck cancers without serious adverse events. However, more randomized controlled trials are still needed to confirm this conclusion.

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“…Поздняя стадия характеризуется постоянной сухостью в ротовой полости; пациенты вынуждены принимать пищу, запивая водой. Даже при интенсивном массировании получить слюну из протоков желез не удается [17].…”

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