A San Francisco Bay Area "Speed" Scene

Carey, James T.; Mandel, Jerry

doi:10.2307/2948335

Cited by 41 publications

(13 citation statements)

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“…METH abuse is associated with a high rate of aggressive behaviors, affective instability, and poor impulse control (Carey and Mandel, 1968;Ellinwood, 1971;Hawks et al, 1969;Szuster, 1990). These observations suggest the possibility that these patients might suffer from dysfunctions within subcortical striato-prefrontal networks that subsume human emotional, cognitive, and social behaviors (Strakowski et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…These issues are compounded by the fact that increased aggressiveness is often observed in patients who suffer from bipolar disorder, major depressive disorder, and antisocial personality disorders (Posternak and Zimmerman, 2002;Swann et al, 2004). Aggressive behaviors are also quite common among abusers of methamphetamine (METH, speed) (Carey and Mandel, 1968;Ellinwood, 1971;Hawks et al, 1969;Miczek and Tidey, 1989;Szuster, 1990). As aggressive behaviors and social interactions can also be influenced by METH in rodents, cats, and non-human primates (Crowley, 1972;Maeda et al, 1985;Miczek and O'Donnell, 1978;Shintomi, 1975;Sokolov et al, 2004), understanding of neuronal adaptations that might be associated with METH-induced aggressiveness in animals should provide a window toward identifying some of the neurobiological substrates that subsume these behaviors.…”

Section: Introductionmentioning

confidence: 99%

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Methamphetamine Causes Alterations in the MAP Kinase-Related Pathways in the Brains of Mice that Display Increased Aggressiveness

Sokolov

Cadet

2005

Neuropsychopharmacol

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Aggressive behaviors have been reported in patients who suffer from some psychiatric disorders, and are common in methamphetamine (METH) abusers. Herein, we report that multiple (but not single) injections of METH significantly increased aggressiveness in male CD-1 mice. This increase in aggressiveness was not secondary to METH-induced hyperactivity. Analysis of protein expression using antibody microarrays and Western blotting revealed differential changes in MAP kinase-related pathways after multiple and single METH injections. There were statistically significant (po0.05) decreases in MEK1, Erk2p, GSK3a, 14-3-3e, and MEK7 in the striata of mice after multiple injections of METH. MEK1 was significantly decreased also after a single injection of METH, but to a much lesser degree than after multiple injections of METH. In the frontal cortex, there was a statistically significant decrease in GSK3a after multiple (but not single) injections of METH. These findings suggest that alterations in MAP kinase-related pathways in the prefronto-striatal circuitries might be involved in the manifestation of aggressive behaviors in mice. Neuropsychopharmacology (2006) 31, 956-966.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Methamphetamine Causes Alterations in the MAP Kinase-Related Pathways in the Brains of Mice that Display Increased Aggressiveness

Sokolov

Cadet

2005

Neuropsychopharmacol

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“…A number of studies have indicated that the social class of psychedelic users is generally middle to upper middle class in significant contrast to narcotic addicts (Carey & Mandel, 1968;Gillie, 1969;Hager et al, 1971;Harris, 1971;Kuehn, 1970;Smart & Fejer, 1969;StefTenhagen, McAree, & Zhevtlin, 1969;Suchman, 1968;Welpton, 1968). This social class distinction is consistent for marijuana users as well as users of the more powerful psychedelic drugs, that is, LSD and methamphetamines.…”

Section: Sociocultural Correlates Of Adolescentmentioning

confidence: 99%

Deviant drug use in adolescence: A review of psychosocial correlates.

Braucht¹,

Brakarsh²,

Follingstad³

et al. 1973

Psychological Bulletin

229

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Research concerning the sociocultural and personality correlates of deviant adolescent use of alcohol, psychedelic drugs, and narcotics was reviewed. A number of consistently replicated findings regarding both personality and sociocultural correlates of adolescent use were found. At the same time, lack of comprehensive, systematic and theory-bound research, gross lack of methodological rigor, and a lack of coordination of effort and integration of findings among the various areas of drug use research were noted. General requirements for the design of future research were also discussed.

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“…The eroticism factor also reflects the use of the needle as an instrument for displacing aggressive behavior. This "gratification in self-destruction" emerging out of the perceived experience of the needle, coupled with the functional substitution of the needle for genital sex, has been discussed in the literature (Howard & Borges 1971;Carey & Mandel 1968). Such "street'' terms as "shoot-up," "hit," "spike" and "fire" connote the aggressive and violent meaning attached to the needle by addicts.…”

Section: Three-factor Modelmentioning

confidence: 99%

Sexual Dynamics and Strength of Heroin Addiction: A Three-Factor Model of an Ideology

TenHouten¹

1982

Journal of Psychoactive Drugs

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The association between heroin addicts' strength of addiction (SOA) and sexuality is documented. A three-factor behaviorally operational model based on psychoanalytic theory was constructed to explain the contingencies of the association. While the family, self and eroticism factors have insignificant main effects on SOA, the effect of the three-factor model as a whole is significant. A type of heroin addict associated with high SOA emerges from the analysis: A male from a surrogate family background, possessing a strongly autonomous impulsive self and finds erotic satisfaction in the needle-specific, pharmacogenic orgasm, as opposed to the genital-specific, physiogenic orgasm.

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A San Francisco Bay Area "Speed" Scene

Cited by 41 publications

References 0 publications

Methamphetamine Causes Alterations in the MAP Kinase-Related Pathways in the Brains of Mice that Display Increased Aggressiveness

Methamphetamine Causes Alterations in the MAP Kinase-Related Pathways in the Brains of Mice that Display Increased Aggressiveness

Deviant drug use in adolescence: A review of psychosocial correlates.

Sexual Dynamics and Strength of Heroin Addiction: A Three-Factor Model of an Ideology

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