A sandwich-type DNA biosensor based on electrochemical co-reduction synthesis of graphene-three dimensional nanostructure gold nanocomposite films

Liu, Ailin; Zhong, Guang‐Xian; Chen, Jin‐Yuan; Weng, Shaohuang; Huang, Hong-Nan; Chen, Wei; Lin, Lin; Lei, Yun; Fu, Fei-Huan; Sun, Zhouliang; Lin, Jianhua; Yang, Shuyu

doi:10.1016/j.aca.2012.12.049

Cited by 69 publications

(38 citation statements)

References 59 publications

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“…Therefore, graphene is a very promising candidate as a new carbonaceous support, and the integration of graphene with AuNPs is beneficial to develop highly sensitive electrochemical sensors for proteins, 216 amino acids, 217 and DNA. 218 For example, Chen et al reported on the fabrication and characterization of a specific IgG detection biosensor using thermally reduced graphene oxide (TRGO) sheets decorated with AuNP-antibody conjugates. This immunosensor avoids nonspecific protein immobilization on graphene/TRGO and provides a stable binding for probe proteins on the robust AuNPs.…”

Section: Aunp-based Electrochemical Assaysmentioning

confidence: 99%

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Gold Nanoparticles for In Vitro Diagnostics

et al. 2015

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Section: Aunp-based Electrochemical Assaysmentioning

confidence: 99%

“…A “sandwich-type” detection strategy was employed, and the detection limit was as low as 3.4 fM. 218 …”

Section: Aunp-based Electrochemical Assaysmentioning

confidence: 99%

Gold Nanoparticles for In Vitro Diagnostics

et al. 2015

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“…During the last 3 years, free‐standing GF, a 3D porous structure, has been fabricated via CVD methodology (Chen et al , ; Lee et al , ; Brownson et al , ) or via hydrothermal methods (Xu et al , ; Nardecchia et al , ; Liu et al , ). They are characterized by routine methods, e.g.…”

Section: Graphene‐based Biomaterials: New Scaffolds For Tissue Enginementioning

confidence: 99%

Graphene nanomaterials as biocompatible and conductive scaffolds for stem cells: impact for tissue engineering and regenerative medicine

Menaa

Abdelghani

Menaa

2014

J Tissue Eng Regen Med

151

112

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The discovery of the interesting intrinsic properties of graphene, a two-dimensional nanomaterial, has boosted further research and development for various types of applications from electronics to biomedicine. During the last decade, graphene and several graphene-derived materials, such as graphene oxide, carbon nanotubes, activated charcoal composite, fluorinated graphenes and three-dimensional graphene foams, have been extensively explored as components of biosensors or theranostics, or to remotely control cell-substrate interfaces, because of their remarkable electro-conductivity. To date, despite the intensive progress in human stem cell research, only a few attempts to use carbon nanotechnology in the stem cell field have been reported. Interestingly, most of the recent in vitro studies indicate that graphene-based nanomaterials (i.e. mainly graphene, graphene oxide and carbon nanotubes) promote stem cell adhesion, growth, expansion and differentiation. Although cell viability in vitro is not affected, their potential nanocytoxicity (i.e. nanocompatibility and consequences of uncontrolled nanobiodegradability) in a clinical setting using humans remains unknown. Therefore, rigorous internationally standardized clinical studies in humans that would aim to assess their nanotoxicology are requested. In this paper we report and discuss the recent and pertinent findings about graphene and derivatives as valuable nanomaterials for stem cell research (i.e. culture, maintenance and differentiation) and tissue engineering, as well as for regenerative, translational and personalized medicine (e.g. bone reconstruction, neural regeneration). Also, from scarce nanotoxicological data, we also highlight the importance of functionalizing graphene-based nanomaterials to minimize the cytotoxic effects, as well as other critical safety parameters that remain important to take into consideration when developing nanobionanomaterials.

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“…Further modification strategies were using graphene-metal nano-composites [16,17]. Among metal nanoparticles CeO 2 (called Ceria) is particularly attractive because of its high catalytic activity and biocompatibility [18,19].…”

Section: A N U S C R I P Tmentioning

confidence: 99%