A Scalable Synthesis of the Antidepressant Agomelatine by a Tandem Allylic Chlorination–Isomerization Process

Stathakis, Christos I.; Neokosmidis, Efstratios; Koftis, Theocharis V.

doi:10.1002/ejoc.201402886

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…Aer a simple re-crystallization, the pure molecule 317 was obtained with a purity of more than 99.5% (Scheme 48). 217,218…”

Section: Iridium-catalysed Reactionsmentioning

confidence: 99%

Synthesis of anti-depressant molecules via metal-catalyzed reactions: a review

Kanwal,

Afzal,

Zubair

et al. 2024

RSC Adv.

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“…Aer a simple re-crystallization, the pure molecule 317 was obtained with a purity of more than 99.5% (Scheme 48). 217,218…”

Section: Iridium-catalysed Reactionsmentioning

confidence: 99%

Synthesis of anti-depressant molecules via metal-catalyzed reactions: a review

Kanwal,

Afzal,

Zubair

et al. 2024

RSC Adv.

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“…7-methoxy-1-tetralone (MT) is mainly used as the organic material or intermediate in chemical engineering currently (12)(13)(14)(15). Our research group revealed that wild Juglansshurica leather has strong anti-tumor effects through the long-term study, while MT may be one of the effective components.…”

Section: Introductionmentioning

confidence: 99%

7-Methoxy-1-Tetralone Induces Apoptosis, Suppresses Cell Proliferation and Migration in Hepatocellular Carcinoma via Regulating c-Met, p-AKT, NF-κB, MMP2, and MMP9 Expression

et al. 2020

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This study aimed to determine the anti-proliferative and anti-migratory effects of 7-methoxy-1-tetralone (MT) in hepatocellular carcinoma (HCC) cells. MTT assay assessed HCC cell viability; cell apoptosis of HCC cells was determined by flow cytometry; wound healing assay evaluated HCC cell migratory ability; protein expression levels were assessed using western blot assay; the in vivo antitumor effects of MT were tested in BALB/c nude mice and the pathological changes within the tumor tissues were evaluated by immunohistochemistry. MT treatment significantly suppressed the cell proliferative and migratory potentials of HepG2 cells, and induced HepG2 cell apoptosis. The western blot assay showed that MT treatment caused a suppression on c-Met, phosphorylated AKT (p-AKT), NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9 protein levels in HepG2 cells. Further in vivo animal studies deciphered that MT treatment suppressed tumor growth of HepG2 cells in the nude mice, but had no effect on the body weight and the organ index of liver and spleen. Further immunohistochemistry analysis of the dissected tumor tissues showed that MT treatment significantly suppressed the protein expression levels of NF-κB, MMP9, MMP2, and p-AKT. In summary, the present study demonstrated the anti-tumor effects of MT on the HCC, and MT suppressed HCC progression possibly via regulating proliferation-and migration-related mediators including c-Met, p-AKT, NF-κB, MMP2, and MMP9 in HepG2 cells.

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