A Scenario of Serum TNF  and #945; and C - Reactive Protein in Acute Ischemic Stroke and their Prognostic Significance

Objectives This study investigated the association between the pre-miRNA146a C>G rs2910164 polymorphism and serum TNF-α in Egyptian patients with IS. Methods A case-control study was conducted on 75 Egyptian cases with IS and 75 sex-matched control subjects aged 57–65 years. Genomic DNA analysis of pre-miRNA146a and TNF-α measurement was performed with real-time PCR and ELISA, respectively. Results There was a statistically significant difference between cases of ischemic stroke (IS) and control subjects in pre-miRNA146a rs2910164 GG genotype (p=0.017) and G allele (p=0.005). The pre-miRNA146a rs2910164 is significantly associated with large artery atherosclerosis [LAA] in GG genotypes (p=0.019) and G alleles (p=0.004) compared to control subjects. There was a highly statistically significant increase in TNF-α levels (p<0.001) in IS compared to the control group. There was also a statistically significant increase in TNF-α levels (p=0.001) in GG genotypes in IS. Conclusions Our results showed that there was a statistically significant association between pre-miRNA146a rs2910164 GG genotype and susceptibility to IS and LAA. In addition, there was a statistically significant association between pre-miRNA146a rs2910164 GG genotype and TNF-α in IS subjects.

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Emerging insights into the relationship between pre-microRNA146a rs2910164 gene polymorphism and TNF-α in ischemic stroke

Elasmer

Zaki

Elgendy

et al. 2022

Turkish Journal of Biochemistry

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Usefulness of selected laboratory markers in stroke diagnosis

et al. 2019

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Strokes and their complications are major clinical and social problems. Stroke diagnosis is limited to clinical and imaging evaluation – mainly by computed tomography (CT), which is particularly low sensitive to early ischemic stroke. Due to diagnostic problems, there are many studies conducted to find a laboratory marker of stroke, which can play similar role to troponins in the diagnosis of acute coronary syndrome. The aim of this article is to review scientific research in which the usefulness of potential stroke markers was assessed. Among analyzed parameters there are: inflammatory mediators (CRP, IL-1, IL-6, TNF– α, MCP-1, MMP-9), neural tissue markers (S100B protein, NSE, GFAP), coagulation and fibrinolysis components (vWF, D-dimer) and other markers – BNP, NT-proBNP, and osteoprotegerin. Some studies show the potential of laboratory markers in the differential diagnosis of the type of stroke, predicting the risk of mortality, or in patient’s condition assessment but yet none of the markers fulfill the criteria of a diagnostic test in stroke.

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A Scenario of Serum TNF and #945; and C - Reactive Protein in Acute Ischemic Stroke and their Prognostic Significance

Cited by 2 publications

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Emerging insights into the relationship between pre-microRNA146a rs2910164 gene polymorphism and TNF-α in ischemic stroke

Emerging insights into the relationship between pre-microRNA146a rs2910164 gene polymorphism and TNF-α in ischemic stroke

Usefulness of selected laboratory markers in stroke diagnosis

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