A Schematic Overview of the Current Status of Male Infertility Practice

Agarwal, Ashok; Majzoub, Ahmad; Parekh, Neel; Henkel, Ralf

doi:10.5534/wjmh.190068

Cited by 62 publications

(52 citation statements)

References 78 publications

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“…This pathology has become a global health issue with a general prevalence of 15%, affecting one out of six couples of reproductive age. According to global statistics, male infertility is the cause of approximately 50% of infertility cases, either as a sole cause or in combination with a female infertility factor [ 85 ]. Semen analysis is the most widely technique used to determine male fertility, but it has become evident that, in many cases, a basic seminogram is insufficient to determine the fertility status of the male partner.…”

Section: Proteomic Landscape Of Sp: a Potential Indicator Of Spermmentioning

confidence: 99%

“…It is known that human SPZ generate reactive oxygen species (ROS) in physiological amounts, which play a role in sperm functions during sperm capacitation, acrosome reaction and oocyte fusion [ 140 ]. However, an excessive production of ROS results in seminal oxidative stress with male infertility as a consequence [ 85 , 136 ]. As previously described, SP contains many proteins and metabolites that coat and protect SPZ from oxidative stress.…”

Section: Proteomic Landscape Of Sp: a Potential Indicator Of Spermmentioning

confidence: 99%

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Exosome Composition and Seminal Plasma Proteome: A Promising Source of Biomarkers of Male Infertility

Candenas

Chianese

2020

IJMS

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Infertility has become a global health issue, with approximately 50% of infertility cases generated by disorders in male reproduction. Spermatozoa are conveyed towards female genital tracts in a safe surrounding provided by the seminal plasma. Interestingly, this dynamically changing medium is a rich source of proteins, essential not only for sperm transport, but also for its protection and maturation. Most of the seminal proteins are acquired by spermatozoa in transit through exosomes (epididymosomes and prostasomes). The high number of seminal proteins, the increasing knowledge of their origins and biological functions and their differential expression in the case of azoospermia, asthenozoospermia, oligozoospermia and teratozoospermia or other conditions of male infertility have allowed the identification of a wide variety of biomarker candidates and their involvement in biological pathways, thus to strongly suggest that the proteomic landscape of seminal plasma may be a potential indicator of sperm dysfunction. This review summarizes the current knowledge in seminal plasma proteomics and its potentiality as a diagnostic tool in different degrees of male infertility.

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Section: Proteomic Landscape Of Sp: a Potential Indicator Of Spermmentioning

confidence: 99%

Section: Proteomic Landscape Of Sp: a Potential Indicator Of Spermmentioning

confidence: 99%

Exosome Composition and Seminal Plasma Proteome: A Promising Source of Biomarkers of Male Infertility

Candenas

Chianese

2020

IJMS

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“…Infertility is defined as the inability of a couple to conceive after at least one year of unprotected intercourse. According to WHO statistics, the inability to procreate has been increasing in recent years, and many couples of childbearing age suffer from this problem [ 1 ]. Numerous studies have shown that women and men share equal responsibility in that situation, i.e., about 30% to 40% for each partner [ 2 ], the remaining share representing cases for which the origin of infertility cannot be attributed to one or the other partner.…”

Section: Introductionmentioning

confidence: 99%

Oxidation of Sperm DNA and Male Infertility

et al. 2021

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One important reason for male infertility is oxidative stress and its destructive effects on sperm structures and functions. The particular composition of the sperm membrane, rich in polyunsaturated fatty acids, and the easy access of sperm DNA to oxidative damage due to sperm cell specific cytologic and metabolic features (no cytoplasm left and cells unable to mount stress responses) make it the cell type in metazoans most susceptible to oxidative damage. In particular, oxidative damage to the spermatozoa genome is an important issue and a cause of male infertility, usually associated with single- or double-strand paternal DNA breaks. Various methods of detecting sperm DNA fragmentation have become important diagnostic tools in the prognosis of male infertility and such assays are available in research laboratories and andrology clinics. However, to date, there is not a clear consensus in the community as to their respective prognostic value. Nevertheless, it is important to understand that the effects of oxidative stress on the sperm genome go well beyond DNA fragmentation alone. Oxidation of paternal DNA bases, particularly guanine and adenosine residues, the most sensitive residues to oxidative alteration, is the starting point for DNA damage in spermatozoa but is also a danger for the integrity of the embryo genetic material independently of sperm DNA fragmentation. Due to the lack of a spermatozoa DNA repair system and, if the egg is unable to correct the sperm oxidized bases, the risk of de novo mutation transmission to the embryo exists. These will be carried on to every cell of the future individual and its progeny. Thus, in addition to affecting the viability of the pregnancy itself, oxidation of the DNA bases in sperm could be associated with the development of conditions in young and future adults. Despite these important issues, sperm DNA base oxidation has not attracted much interest among clinicians due to the lack of simple, reliable, rapid and consensual methods of assessing this type of damage to the paternal genome. In addition to these technical issues, another reason explaining why the measurement of sperm DNA oxidation is not included in male fertility is likely to be due to the lack of strong evidence for its role in pregnancy outcome. It is, however, becoming clear that the assessment of DNA base oxidation could improve the efficiency of assisted reproductive technologies and provide important information on embryonic developmental failures and pathologies encountered in the offspring. The objective of this work is to review relevant research that has been carried out in the field of sperm DNA base oxidation and its associated genetic and epigenetic consequences.

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“…A decrease in semen parameter values is expected from the age above 40 years old [ 29 ]. Similarly, the mean BMI in the analyzed sample was 23.74 (SD ± 2.56), with most of the individuals corresponding to the “normal weight” category, meaning that in this study the already known association of sperm parameters and a high BMI was not present [ 30 ]. Consequently, the observed decrease of semen parameter values occurs in an otherwise healthy population of possible fertile men.…”

Section: Discussionmentioning

confidence: 78%

Decline of semen quality over the last 30 years in Uruguay

Rosa-Villagrán

Barrera²,

Montes³

et al. 2021

Basic Clin. Androl.

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Background Over the last years, there has been an increasing concern about a global decline in men’s fertility. Specifically, some evidence indicates that sperm quality has decreased over the last years. However, reports showing the changes in sperm quality with time are inconsistent. Part of the contradictions between studies is attributed to geographical differences. Surprisingly, few studies include data from South American countries, creating a bias in the conclusions. This study aims to determine how sperm quality has evolved over the past 30 years in Uruguay. For this purpose, 317 medical records from allegedly healthy sperm donor candidates, aged between 18 and 36 years old, who voluntarily requested to be considered as sperm donors between 1988 and 2019, were analyzed. The studied variables were the following sperm parameters: semen volume, sperm cell concentration, total sperm number, progressive motility, vitality, and sperm morphology. A correlative statistical analysis was performed between seminal parameter values and the year data were collected. Results We found a statistically significant decrease in sperm concentration and normal sperm morphology during the studied period. There was no decrease in vitality, seminal volume, and total progressive motility. Semen parameters were not associated with tobacco, drugs, or alcohol consumption. Conclusions We conclude that the sperm quality of donor candidates in Uruguay decreased during this period. Further studies should be carried out to verify the occurrence of this phenomenon in the general population and find its possible causes.

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A Schematic Overview of the Current Status of Male Infertility Practice

Cited by 62 publications

References 78 publications

Exosome Composition and Seminal Plasma Proteome: A Promising Source of Biomarkers of Male Infertility

Exosome Composition and Seminal Plasma Proteome: A Promising Source of Biomarkers of Male Infertility

Oxidation of Sperm DNA and Male Infertility

Decline of semen quality over the last 30 years in Uruguay

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