A Scheme for the Ante‐Natal Prediction of ABO Haemolytic Disease of the Newborn

Ames, A. C.; Lloyd, R. S.

doi:10.1111/j.1423-0410.1964.tb04068.x

Cited by 11 publications

(7 citation statements)

References 7 publications

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“…In contrast, in a previous investigation of a larger material an increasing frequency of haemolysins with increasing number of pregnancies has been found [Ames and Lloyd, 1964], This discrepancy is most likely due to the relative smallness of the present series. There was no correlation between C3 phenotypes and the number of pregnancies in the present material, however, which could cause a spurious correlation between C3S and antibody titre.…”

Section: Discussioncontrasting

confidence: 53%

Studies of the C3 Polymorphism

Brönneståm¹,

Cedergren²

1973

Hum Hered

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The relationship between C3 phenotypes and anti bodies against blood group antigens A and B were studied in 251 sera from newly delivered mothers and in 289 blood donor sera. Among the mothers an association was found between high titres of anti-A or anti-B and the C3^S gene. This difference was most pronounced in cases of ABO incompatibility between mother and infant thus suggesting an association between C3 types and immune antibodies. Among the blood donors no association was found between C3 type and isoagglutinin titre.

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Section: Discussioncontrasting

confidence: 53%

Studies of the C3 Polymorphism

Brönneståm¹,

Cedergren²

1973

Hum Hered

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“…Many attempts have been made to achieve this aim by use of the titre of 'non-inhibitable' antibodies based on the work of Witebsky [65] and serum [65], accaicia [28] dextrans [36] as well an antiglobulin reagents [1,13,14,15,68] have all been used to demonstrate the 'non-inhibitable' antibodies following partial neutralisation of the sera with soluble blood group A/B substances.…”

Section: Discussionmentioning

confidence: 99%

“…occur in approximately 25% of all group O maternal sera ( [13] and table VI) the incidence of ABO HD is rela tively low, [1,12,34,36,42,43,51,53,54] occurring in only about 0.8% of all the infants of group O mothers.…”

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confidence: 99%

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A Detailed Serological Study on the Prediction and Diagnosis of ABO Haemolytic Disease of the Newborn (ABO HD)

Bowley¹,

Voak²

1969

Vox Sanguinis

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An evaluation is given of haemolysin, neutralisation, thermostability, saline titration, anti-A® antibody absorption and 2-mercapto-ethanol studies on the sera from 178 clinically affected ABO HD cases and 130 control cases. The antiglobulin titre on the 2-mercapto-ethanol treated sera which determines the IgG titre was the best procedure used for the demonstration of significant immune anti-A/B antibodies in the maternal sera. The screen series on 5,704 sera from group 0 mothers for the detection of immune anti-A/B and the attempted prediction of ABO HD revealed that ABO HD occurs with a frequency of about 0.8%. Exchange transfusion was needed in six cases i.e. about 0.1% of all the infants of group 0 mothers screened. The minimum criteria for the diagnosis of ABO HD are the serological demonstration of incompatible anti-A/B antibodies in an eluate prepared from the baby’s red cells, accompanied by the clinical observation of jaundice, or more rarely pallor due to anaemia, in the infant during the first few days following birth. In the absence of elution or serum studies on a blood sample from the baby, the presence of an incompatible high titre (>256) IgG antibody in the maternal serum provides good presumptive evidence that the baby may be suffering from ABO HD.

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“…25 Severe ABO HDFN which required exchange transfusion was relatively rare in few analyses; none among 1500 neonates in one study, 3 out of 14,000 consecutive births in another study, 3 out of 8000 births in a third study and 6 out of 5704 infants in fourth one. 26,27,28 Falterman C G and Richardson J has observed that transfusion of adult A or B red cells with more antigenic sites might undergo rapid destruction which could result in severe jaundice, kernicterus, haemoglobinuria and even death. 29 In a Saudi Arabian research, the value of phototherapy along with IVIG was compared with phototherapy alone in reducing the requirement for exchange transfusion in ABO HDFN.…”

Section: Parametersmentioning

confidence: 99%