A Schistosoma japonicum MicroRNA Exerts Antitumor Effects Through Inhibition of Both Cell Migration and Angiogenesis by Targeting PGAM1

Hu, Chao; Li, Yuzhen; Pan, Danting; Wang, Jing; Zhu, Liufang; Lin, Yu; Zhu, Shanli; Pan, Weiqing

doi:10.3389/fonc.2021.652395

Cited by 5 publications

(4 citation statements)

References 34 publications

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“…Moreover, a study has shown that PGAM1 interacts with ACTA2 (unrelated to its metabolic activity) to promote actin filaments assembly, cancer cell migration, and cell motility [ 39 ]. Previous studies have shown that PGAM1 promotes cancer progression by inducing angiogenesis [ 40 , 41 ]. Therefore, our results revealed an in-depth and comprehensive mode of action of PGAM1 in cancers.…”

Section: Discussionmentioning

confidence: 99%

Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1

Luo

Yang

et al. 2023

Cell Death Dis

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Tumor-derived exosomes and their contents promote cancer metastasis. Phosphoglycerate mutase 1 (PGAM1) is involved in various cancer-related processes. Nevertheless, the underlying mechanism of exosomal PGAM1 in prostate cancer (PCa) metastasis remains unclear. In this study, we performed in vitro and in vivo to determine the functions of exosomal PGAM1 in the angiogenesis of patients with metastatic PCa. We performed Glutathione-S-transferase pulldown, co-immunoprecipitation, western blotting and gelatin degradation assays to determine the pathway mediating the effect of exosomal PGAM1 in PCa. Our results revealed a significant increase in exosomal PGAM1 levels in the plasma of patients with metastatic PCa compared to patients with non-metastatic PCa. Furthermore, PGAM1 was a key factor initiating PCa cell metastasis by promoting invadopodia formation and could be conveyed by exosomes from PCa cells to human umbilical vein endothelial cells (HUVECs). In addition, exosomal PGAM1 could bind to γ-actin (ACTG1), which promotes podosome formation and neovascular sprouting in HUVECs. In vivo results revealed exosomal PGAM1 enhanced lung metastasis in nude mice injected with PCa cells via the tail vein. In summary, exosomal PGAM1 promotes angiogenesis and could be used as a liquid biopsy marker for PCa metastasis.

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Section: Discussionmentioning

confidence: 99%

Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1

Luo

Yang

et al. 2023

Cell Death Dis

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“…Recent studies have found that the parasitic miRNAs sja-miR-7-5p, sja-miR-61, and sja-miR-3096 have significant negative effects on the growth of hepatoma cell in vitro and in vivo , but no effect in normal non-cancerous cells ( Hu et al, 2019 ; Lin et al, 2019 ; Hu et al, 2021 ). Although the current study does not confirm the involvement of SjEVs during liver cancer, in-depth studies of cross-species miRNA regulation may help to discover new strategies for the prevention and treatment of parasitic diseases, including schistosomiasis.…”

Section: Micrornas In the Host-parasite Interactionmentioning

confidence: 99%

Multifunctional Roles of MicroRNAs in Schistosomiasis

Zhong

Jin

2022

Front. Microbiol.

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Schistosomiasis is a parasitic disease that is caused by helminths of the genus Schistosoma. The dioecious schistosomes mate and lay eggs after undergoing a complex life cycle. Schistosome eggs are mostly responsible for the transmission of schistosomiasis and chronic fibrotic disease induced by egg antigens is the main cause of the high mortality rate. Currently, chemotherapy with praziquantel (PZQ) is the only effective treatment against schistosomiasis, although the potential of drug resistance remains a concern. Hence, there is an urgent demand for new and effective strategies to combat schistosomiasis, which is the second most prevalent parasitic disease after malaria. MicroRNAs (miRNAs) are small non-coding RNAs that play pivotal regulatory roles in many organisms, including the development and sexual maturation of schistosomes. Thus, miRNAs are potential targets for treatment of schistosomiasis. Moreover, miRNAs can serve as multifunctional “nano-tools” for cross-species delivery in order to regulate host-parasite interactions. In this review, the multifunctional roles of miRNAs in the growth and development of schistosomes are discussed. The various regulatory functions of host-derived and worm-derived miRNAs on the progression of schistosomiasis are also thoroughly addressed, especially the promotional and inhibitory effects on schistosome-induced liver fibrosis. Additionally, the potential of miRNAs as biomarkers for the diagnosis and treatment of schistosomiasis is considered.

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“…The overexpression of S. japonicum miRNAs with tumor-suppressor activity could function as potential therapy for cancer. It has been noted that Sja-mir-61 can inhibit the migration of liver tumor cells in vitro, and its molecular mechanism was found to involve the binding of Sja-mir-61 to the 3′-UTR region of oncogene phosphoglycerate mutase 1 (PGAM1), diminishing its expression [ 93 ]. Moreover, Sja-mir-61 was found to inhibit tumoral growth in a murine tumor model and showed antiangiogenic properties [ 93 ].…”

Section: Mirnas Of Schistosoma Japonicummentioning

confidence: 99%

“…It has been noted that Sja-mir-61 can inhibit the migration of liver tumor cells in vitro, and its molecular mechanism was found to involve the binding of Sja-mir-61 to the 3′-UTR region of oncogene phosphoglycerate mutase 1 (PGAM1), diminishing its expression [ 93 ]. Moreover, Sja-mir-61 was found to inhibit tumoral growth in a murine tumor model and showed antiangiogenic properties [ 93 ]. Sja-mir-7-5p is another miRNA with reported tumor-suppression activity and with a homologous miRNA in humans.…”

Section: Mirnas Of Schistosoma Japonicummentioning

confidence: 99%

Roles of microRNAs and Long Non-Coding RNAs Encoded by Parasitic Helminths in Human Carcinogenesis

Leija-Montoya

González-Ramírez

Martínez-Coronilla

et al. 2022

IJMS

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Infectious agents such as viruses, bacteria, and parasites can lead to cancer development. Infection with the helminthic parasite Schistosoma haematobium can cause cancer of the urinary bladder in humans, and infection with the parasites Clonorchis sinensis and Opisthorchis viverrini can promote cholangiocarcinoma. These three pathogens have been categorized as “group 1: carcinogenic to humans” by the International Agency for Research on Cancer (IARC). Additionally, the parasite Schistosoma japonicum has been associated with liver and colorectal cancer and classified as “group 2B: possibly carcinogenic to humans”. These parasites express regulatory non-coding RNAs as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), which modulate genic expression in different biological processes. In this review, we discuss the potential roles of miRNAS and lncRNAs encoded by helminthic parasites that are classified by the IARC as carcinogenic and possibly carcinogenic to humans. The miRNAs of these parasites may be involved in carcinogenesis by modulating the biological functions of the pathogen and the host and by altering microenvironments prone to tumor growth. miRNAs were identified in different host fluids. Additionally, some miRNAs showed direct antitumoral effects. Together, these miRNAs show potential for use in future therapeutic and diagnostic applications. LncRNAs have been less studied in these parasites, and their biological effects in the parasite–host interaction are largely unknown.

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A Schistosoma japonicum MicroRNA Exerts Antitumor Effects Through Inhibition of Both Cell Migration and Angiogenesis by Targeting PGAM1

Cited by 5 publications

References 34 publications

Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1

Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1

Multifunctional Roles of MicroRNAs in Schistosomiasis

Roles of microRNAs and Long Non-Coding RNAs Encoded by Parasitic Helminths in Human Carcinogenesis

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