Adverse Drug Reactions in the Orofacial Region

Abstract

A wide spectrum of drugs can sometimes give rise to numerous adverse orofacial manifestations, particularly dry mouth, taste disturbances, oral mucosal ulceration, and/or gingival swelling. There are few relevant randomized double-blind controlled studies in this field, and therefore this paper reviews the data from case reports, small series, and non-peer-reviewed reports of adverse drug reactions affecting the orofacial region (available from a MEDLINE search to April, 2003). The more common and significant adverse orofacial consequences of drug therapy are discussed.

Reação liquenoide à carbamazepina em mucosa bucal: relato de caso

“…8,9 The findings of this case are consistent with what has been observed in other reports showing that the appearance of LDR generally occurs a long time after the patient has started the use of the medication which induces the lichenoid reaction that, in this case, occured 12 months after the use of carbamazepine. 3,5,8 In accordance with similar studies, the latency period for the appearance of LDR type lesions can vary from 2 months to 3 years, depending on the type of medication involved, being longer for the penicillamine 5 .…”

“…1,2,3,4,5 Considering that there is no specific test to diagnose LDR the most accepted criterion is based on the observation of improvement or disapearance of the lesions after withdrawal of medication added to recurrence of the lesions when medication is reintroduced. 6,7,8,9 LDsR are more frequent in the skin than in the oral mucosa. 6,8,9 The present article emphasizes the diagnostic process in a case of LDR in the oral mucosa associated with the use of carbamazepine.…”

“…6,7,8,9 LDsR are more frequent in the skin than in the oral mucosa. 6,8,9 The present article emphasizes the diagnostic process in a case of LDR in the oral mucosa associated with the use of carbamazepine.…”

Analysis of a possible association between oral lichen planus and drug intake. A controlled study

“…Additionally, it is very difficult to identify the drug associated to LDR based on the patient's medical history. The best criterion for diagnosing LDR is based on the observation that the lesion remits with drug withdrawal and returns on re-challenge, but this is almost always impractical because of the need for patient safety (6)(7)(8)(9). Many types of drugs have been implicated as a causative factor for LDR, especially the non-steroidal antiinflammatory drugs.…”

Paliperidon palmitata bağlı gelişen siyah kıllı dil

“…Daha çok erkeklerde, ağır sigara içenlerde, alkoliklerde, çok çay kahve tüketenlerde, yaşlı ve dişsiz olanlarda, HIV hastalarında görülür 12,14 . Çeşitli tetikleyici faktörler arasında geniş spektrumlu antibiyotikler (tetrasiklin, amoksisilin), bazı diş macunları, oksitleyici ajanlar, kötü ağız hijyeni ve radyasyon tedavisi sayılabilir 9 .…”