Asplit‐face, blind, randomized placebo‐controlled clinical trial investigating the efficacy and safety of hyaluronic acid filler for the correction of atrophic facial scars

Abstract

Background: Hyaluronic acid fillers have been studied extensively for facial wrinkles; however, their efficacy for atrophic facial scars has yet to be analyzed in a prospective placebo-controlled study. Objective:To analyze the efficacy and safety of a hyaluronic acid filler for atrophic facial scars.Methods & Materials: Fifteen subjects were randomized to receive up to 1 ml of VYC-17.5 L on one cheek and up to 1 ml of saline on the other side, with an optional touch-up treatment. Subjects were graded by a live blind evaluator using the Quantitative Global Scarring Grading System (QGSGS) (J Cosmet Dermatol. 2006;5:48), the Global Aesthetic Improvement Scale (GAIS), and Canfield photo-analysis.Results: According to the blind evaluator, there was a significant reduction 90 days after the last treatment on the QGSGS for VYC-17.5L compared with saline (−6.6 VYC-17.5L vs −1.7 saline [t(28) = −4.3196, p = 0.008]). There was a smaller, but still significant reduction on the QGSGS for saline alone (10.4 to 8.6 [t(14) = −3.453, p = 0.004]). In addition, 93% (13/14) of subjects chose VYC-17.5L over saline treatment and reported an improvement on the GAIS. There were no serious side effects and all minor side effects resolved by Day 30. Conclusion:VYC-17.5L achieved significant improvements in rolling atrophic scars as compared to saline, though saline also had modest improvements.

Combination Procedure for Acne Scars Revision, Is It Needed?

“…20 Dermal injection of HA revealed a significant reduction in the number of atrophic rolling scars as compared to saline without any significant side effects. 21 Microneedle RF (MRF) uses microneedles that deliver electrical current to the dermal structures at the desired depth without causing any epidermal damage (non-ablative). The heat delivered via MRF has been associated with both short-term (tightening of collagen in the helical structure) and long-term (fibroblast activation, collagen production, and tissue regeneration) effects.…”