A screening test for capsaicin-stimulated salivary flow using filter paper: a study for diagnosis of hyposalivation with a complaint of dry mouth

Kanehira, Takashi; Yamaguchi, Tomotaka; Asano, Kozo; Morita, Manabu; Maeshima, Etsuko; Matsuda, Ayaka; Fujii, Yoshihiro; Sakamoto, Wataru

doi:10.1016/j.tripleo.2011.02.036

Cited by 13 publications

(12 citation statements)

References 25 publications

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“…Dry mouth, also known as xerostomia, is defined as a subjective feeling of dryness in the oral cavity, as a result of a decline in saliva in the mouth due to salivary gland dysfunction, radiological treatment, Sjögren’s syndrome, or adverse reactions to other medications such as anticholinergic agents, antihistamines, and opioids 1,2. Saliva plays crucial roles not only in lubricating the oral mucosa and teeth, facilitating taste sensation, but also in providing antimicrobial activity in the epithelial membrane.…”

Section: Introductionmentioning

confidence: 99%

Facilitated saliva secretion and reduced oral inflammation by a novel artificial saliva system in the treatment of salivary hypofunction

Kang

Park

Jun

et al. 2017

DDDT

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Saliva substitutes and/or lubricants are commonly employed to lessen dry mouth symptoms by stimulating and/or substituting for the secretion of saliva. In this study, a novel artificial saliva containing inorganic salts, including sodium chloride and potassium chloride, and bactericidal agents, including potassium thiocyanate and lactoperoxidase, was formulated in the form of a solution (DM-sol) or gel (DM-gel). Those in vivo therapeutic efficacies were assessed in terms of saliva secretion and anti-inflammatory activity in rats and mice, respectively. Salivary secretion was promoted by mucosal application of DM-formulations in normal rats. In particular, DM-gel resulted in 2.5- and 1.9-fold greater salivary flow rates compared to normal saline and DM-sol, respectively. In an in vivo efficacy evaluation in diabetic mice with salivary hypofunction, repeated application of DM-formulations alleviated histopathological changes in the buccal mucosa in terms of atrophy and thinning of the epithelium, compared to vehicle, after 4 weeks. Moreover, the DM-sol and DM-gel were comparably effective for relieving periodontal gingivitis, reducing infiltration of inflammatory cells, and normalizing the neutrophil level in the gingival gingiva, after 4 weeks. Therefore, the novel artificial saliva is expected to facilitate salivary secretion and restore physiological conditions in the mouth of patients with salivary hypofunction.

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Section: Introductionmentioning

confidence: 99%

Facilitated saliva secretion and reduced oral inflammation by a novel artificial saliva system in the treatment of salivary hypofunction

Kang

Park

Jun

et al. 2017

DDDT

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“…On the other hand, it is well known that the flow rate of stimulated whole saliva is significantly associated with resting whole saliva. 16,17 However, the previous method was not available for estimation of the citric acidestimulated submandibular and sublingual secretions, 8 in spite of the finding that the highest flow rate was elicited by citric acid followed by mechanical stimulation and the odor of Fig. 2.…”

Section: Discussionmentioning

confidence: 99%

“…A solution of 40 mL of capsaicin or citric acid solution dissolved in ethanol penetrated to the tip of the filter paper as described previously. 8 The papers were allowed to dry at room temperature for 1 hour and then tightly wrapped with aluminum foil and kept at 4 C to prevent loss of the stimulus.…”

Section: Preparation Of Filter Paper For Estimation Of Resting Submanmentioning

confidence: 99%

“…This method can easily estimate both resting and stimulated submandibular and sublingual secretions at one time not only in healthy persons but also in bedridden and disabled elderly persons. 8 However, the method requires the addition of coloring reagents on the paper for the measurement of the secretions. In addition, it is not available for measurement of citric acidestimulated secretions, because citric acid interferes with the iodinestarch reaction on the filter paper.…”

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A simple test for salivary gland function measuring resting and stimulated submandibular and sublingual secretions

Kanehira

Hongou

Asano

et al. 2014

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…Therefore, capsaicin should also stimulate salivation and increase salivary flow in patients with autoimmune diseases. However, salivary responses to capsaicin in patients with autoimmune diseases have not been extensively studied [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Residual Salivary Secretion Ability May Be a Useful Marker for Differential Diagnosis in Autoimmune Diseases

Maeshima

Koshiba

Furukawa³

et al. 2014

Disease Markers

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Background. We have elucidated decreased resting salivary flow in approximately 60% of patients with autoimmune diseases not complicated by Sjögren syndrome (SjS). In this study, salivary stimulation tests using capsaicin were performed to examine residual salivary secretion ability in patients with autoimmune diseases. Materials and Methods. Fifty-eight patients were divided into three groups: patients with primary or secondary SjS (SjS group), patients with systemic sclerosis not complicated by SjS (SSc group), and patients with other autoimmune diseases (non-SjS/non-SSc group). Simple filter paper and filter paper containing capsaicin were used to evaluate salivary flow rates. Results. Resting salivary flow rates were significantly lower in the SjS and SSc groups than in the non-SjS/non-SSc group but did not differ significantly between the SjS and SSc groups. Capsaicin-stimulated salivary flow rates were significantly lower in the SjS and SSc groups than in the non-SjS/non-SSc group, but not significantly different between the SjS and SSc groups. In the non-SjS/non-SSc group, salivary flow rates increased after capsaicin stimulation to the threshold level for determination of salivary gland dysfunction, whereas no improvement was observed in the SjS and SSc groups. Conclusion. Residual salivary secretion ability may be a useful marker for differential diagnosis in autoimmune diseases.

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A screening test for capsaicin-stimulated salivary flow using filter paper: a study for diagnosis of hyposalivation with a complaint of dry mouth

Cited by 13 publications

References 25 publications

Facilitated saliva secretion and reduced oral inflammation by a novel artificial saliva system in the treatment of salivary hypofunction

Facilitated saliva secretion and reduced oral inflammation by a novel artificial saliva system in the treatment of salivary hypofunction

A simple test for salivary gland function measuring resting and stimulated submandibular and sublingual secretions

Residual Salivary Secretion Ability May Be a Useful Marker for Differential Diagnosis in Autoimmune Diseases

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