A Sealless Centrifugal Blood Pump Suspended With Synergistic Passive Magnetic and Hydrodynamic Bearings

Wampler, Richard K.; Lancisi, David; Gauthier, Romain; Indravudh, V.; Cao, Huai; Lin, Fanyun; Fine, R B

doi:10.1097/00002480-199903000-00215

Cited by 2 publications

(2 citation statements)

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“…In summary, shared characteristics of these TAHs include: 1) All are valveless. OregonHeart, 29 RollingHeart, 30 MagVad TAH, 31 and the centrifugal/axial family of TAHs (Dragon Heart, 32 CFTAH, 33 p-CFTAH, 34 IB-Heart, 35 etc) are also valveless designs. OregonHeart uses a rotor to alternatively shuttle between the systemic and pulmonic positions without the need of valves.…”

Section: Discussionmentioning

confidence: 99%

“…30 MagVad TAH uses a nutating disc mechanism with a two-chamber design that also does not require valves. 31 Dragon Heart utilizes a centrifugal pump and axial pump nested together with separate fluid paths. 32 While the Aeson has valves, it uses hybrid membranes (bovine pericardial tissue and polyurethane) to minimize complications associated with mechanical valves, 6 as they are associated with increased risk of thrombus (particularly at the bi-leaflet hinge and hinge areas) and require the need for anticoagulation.…”

Section: Discussionmentioning

confidence: 99%

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Anatomical and Hemodynamic Characterization of Totally Artificial Hearts

Monreal,

Koenig,

Huang

et al. 2024

ASAIO Journal

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We characterize the anatomy and function of never before studied total artificial hearts (TAHs) using established methods for testing mechanical circulatory support (MCS) devices. A historical review of TAHs is also presented to aid in benchmarking performance metrics. Six TAHs, ranging from spooky Halloween beating hearts to a cute colorful plush heart, were imaged, instrumented (mock flow loops) to measure their pressure, volume, and flow, and qualitatively evaluated by 3rd party cardiac surgeons for anatomical accuracy and surgical considerations. Imaging of Claw, Beating, and Frankenstein TAHs revealed internal motors, circuit boards, and speakers. Gummy TAH was ranked favorite TAH for tactile realism, while Frankenstein TAH had the most favorable audible/visual indicators, including an illuminated Jacob’s Ladder. Beating TAH demonstrated superior pulsatile hemodynamic performance compared to Claw TAH (16mL vs 1.3mL stroke volume). Light Up TAH and Gummy TAH functioned only as passive compliance chambers. Cute TAH rapidly exsanguinated due to its porosity (-3.0 L/min flow). These TAHs demonstrated a wide range of anatomical accuracy, surgeon appeal, unique features, and hemodynamic performance. While Claw TAH and Beating TAH successfully generated a modicum of pulsatility, we recommend the clinical community continue to support pre-clinical development of emerging or use of clinically-approved TAHs.

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