A search for anti-viral properties in Panamanian medicinal plants.

Matsuse, Ines Tomoco; Lim, Yasmina Aura; Hattori, Masao; Correa, Mireya; Gupta, Mahabir P.

doi:10.1016/s0378-8741(98)00099-3

Cited by 90 publications

(47 citation statements)

References 10 publications

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“…The leaves of J. curcas also contain apigenin, vitexin and isovitexin which along with other factors enable them to be used against malaria, rheumatic and muscular pains (Thomas et al, 2008). Antibiotic activity of Jatropha has been observed against organisms including Staphylococcus aureus and Escherichia coli (Matsuse et al, 1998). Crude stem bark extracts of J. curcas were reported to inhibit the growth of pathogenic bacteria and fungi (Igbinosa et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Larvicidal effects of Jatropha curcas L. against Anopheles arabiensis (Diptera: Culicidea)

Tomass¹,

Hadis²,

Taye³

et al. 2011

mejs

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Crude and column chromatographic fractions of methanol leaf extract of Jatropha curcas were tested for their larvicidal activities against laboratory reared late third instar larvae of Anopheles arabiensis. Crude methanol leaf extract of J .curcas had similar larvicidal activity to 0.5 ppm Temephos (positive control) at test concentrations ranging from 125 -1000 ppm while column chromatographic fractions (F 1 and F 2 ) of the crude methanol leaf extract of J.curcas showed similar larvicidal activities to 0.5 ppm Temephos at 62.5 and 125 ppm test concentrations. Column chromatographic fraction three ( . Thus, the larvicidal activity of crude methanol leaf extract was not due to the synergistic effects of its fractions. Further studies are recommended to identify larvicidal active ingredients from the active column chromatographic fractions of crude methanol leaf extract of J. curcas.

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Section: Introductionmentioning

confidence: 99%

Larvicidal effects of Jatropha curcas L. against Anopheles arabiensis (Diptera: Culicidea)

Tomass¹,

Hadis²,

Taye³

et al. 2011

mejs

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show abstract

“…Várias plantas foram identificadas como possuidoras de potente atividade anti-HIV baseada em testes celulares, mas algumas não possuem o mecanismo de ação estabelecido [50][51][52] (Tabela 5). Em geral, a avaliação da inibição da replicação do HIV se dá pela pesquisa de efeitos citopáticos, quantificação da p24 e da TR.…”

Section: Outras Atividades Anti-hiv De Produtos Naturaisunclassified

HIV: mecanismo de replicação, alvos farmacológicos e inibição por produtos derivados de plantas

Ferreira¹,

Riffel²,

Santana³

2010

Quím. Nova

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“…The leaves of J. curcas also contain apigenin, vitexin and isovitexin, which, along with other factors enable them to be used against malaria, rheumatic and muscular pains [18]. Antibiotic activity of Jatropha has been observed against organisms including S. aureus and E. coli [8]. Crude stem bark extracts of J. curcas Linn.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Jatropha curcas Linn. leaf extracts for its cytotoxicity and potential to inhibit hemagglutinin protein of influenza virus

et al. 2013

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Influenza is a serious respiratory illness which can be debilitating and cause complications that lead to hospitalization and death. Although influenza vaccine can prevent influenza virus infection, the only therapeutic options to treat influenza virus infection are antiviral agents. Given temporal and geographic changes and the shifts in antiviral drug resistance among influenza viruses, it is time to consider natural antiviral agents against influenza virus. Jatropha curcas is known for various medicinal uses. Its antimicrobial, anti-cancer and anti-HIV activity has been well recognized. Because of its broadspectrum activity, we investigated aqueous and methanol leaf extracts for cytotoxicity and its potential to inhibit hemagglutinin protein of influenza virus. The bioactive compounds from leaf extracts were characterized by highperformance thinlayer chromatography which revealed the presence of major phytochemicals including flavonoids, saponins and tannins. The cytotoxic concentration 50 for aqueous and methanol extracts were determined using trypan blue dye exclusion assay. Inhibition of hemagglutinin protein was assessed using minimal cytotoxic concentrations of the extracts and 10 2.5 TCID50 (64 HA titre) of the Influenza A (H1N1) virus with different exposure studies using hemagglutination assay. Aqueous and methanol extracts were found to be non toxic to Madin darby canine kidney cells below concentration of 15.57 and 33.62 mg/mL for respectively. Inhibition of hemagglutinin was studied using reducing hemagglutination titre which confirmed that the J. curcas extracts have direct effect on the process of virus adsorption leading to its inhibition. Our results provide the information which shows the potential of Jatropha extracts in the treatment of influenza A (H1N1) virus infection. With an established reduced toxicity and prevention of infection by inhibiting hemagglutinin protein, these extracts and its derivatives may be further developed as broad spectrum anti-influenza drugs for prevention and treatment of infections by different types of influenza viruses with further mechanistic studies on antiinfluenza.

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A search for anti-viral properties in Panamanian medicinal plants.

Cited by 90 publications

References 10 publications

Larvicidal effects of <i>Jatropha curcas</i> L. against <i>Anopheles arabiensis</i> (Diptera: Culicidea)

Larvicidal effects of <i>Jatropha curcas</i> L. against <i>Anopheles arabiensis</i> (Diptera: Culicidea)

HIV: mecanismo de replicação, alvos farmacológicos e inibição por produtos derivados de plantas

Evaluation of Jatropha curcas Linn. leaf extracts for its cytotoxicity and potential to inhibit hemagglutinin protein of influenza virus

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