A selective and rapid method for the quantification of captopril in human plasma using liquid chromatography/selected reaction monitoring mass spectrometry

Salem, Isam Ismail; Saif, Weasm Abu; Jmeian, Yazen; Tamimi, Jaafar I Al

doi:10.1016/j.jpba.2004.07.039

Cited by 39 publications

(30 citation statements)

References 12 publications

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“…Several liquid chromatographic methods were applied for determination of captopril in plasma using mass detection (Borges et al, 2006;Chik et al, 2014;Du, 2007;Rezende et al, 2007;Salem et al, 2005;Vancea et al, 2009). The aim of the present work was to apply the most suitable conditions to obtain high throughput method that can be applied for the analysis of captopril in plasma samples obtained from a bioequivalence study.…”

Section: Resultsmentioning

confidence: 99%

“…Several liquid chromatographic methods were applied for determination of captopril in plasma using UV detection, (Bald and Sypniewski, 1997;Bald et al, 1996;Ding et al, 2001;Foroutan et al, 2003;Hadjmohammadi et al, 2008;Huang et al, 2006;Jankowski et al, 1995;Li et al, 1996 ;Sultan et al, 2013;Sypniewski and Bald, 1996) fluorescence detection (Aykin et al, 2001;Kok et al, 1997;Tache et al, 2002) or mass detection (Borges et al, 2006;Chik Z et al, 2014;Du, 2007;Rezende et al, 2007;Salem et al, 2005;Vancea et al, 2009) using either protein precipitation, solid phase extraction or liquid-liquid extraction for sample preparation prior to analysis.…”

Section: Introductionmentioning

confidence: 99%

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A Liquid Chromatography/Tandem Mass Spectrometric Method for Determination of Captopril in Human Plasma: Application to a Bioequivalence Study

2017

J App Pharma Sci

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A simple, rapid and sensitive ultra-performance liquid chromatography/positive ion electrospray tandem mass spectrometric method was developed and validated for the quantification of captopril in human plasma. Following plasma protein precipitation, the analyte and internal standard Rosuvastatin were separated by ultraperformance liquid chromatography using a gradient mode mobile phase on a reversed -phase column and analyzed by mass spectrometry in the multiple reaction monitoring mode (MRM) using the respective [MRH]R ions, m/z 218.09/116.16 for captopril and m/z 482.2/ 258.17 for the internal standard. The method exhibited a linear dynamic range of 10-2000 ng/mL for captopril in human plasma. The lower limit of quantification was 10 ng/mL with a relative standard deviation of less than 6%. Acceptable precision and accuracy were obtained for concentrations over the standard curve range. A total run time of 3 minutes for each sample made it possible to analyze more than 20 human plasma samples per one hour. The validated method has been successfully applied to analyze human plasma samples in a bioequivalence study of captopril after oral administration of 50 mg captopril tablet to 24 healthy subjects.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Liquid Chromatography/Tandem Mass Spectrometric Method for Determination of Captopril in Human Plasma: Application to a Bioequivalence Study

2017

J App Pharma Sci

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“…In biological fluids CAP has been determined by gas chromatography [70][71][72], kinetic spectrophotometry [73], HPLC [74][75][76][77] and HPLC with fluorimetric detection after pre [78,79] or post [80] column derivatization.…”

Section: Research Articlementioning

confidence: 99%

Spectrofluorimetric Estimation of Some Sulfhydryl–Containing Drugs by Demasking Reaction of the Palladium Chelate of 8-Hydroxyquinoline-5-Sulfonic Acid

Rs¹,

Sf²,

Hewala³

et al. 2017

Pharm Anal Acta

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A simple and sensitive spectrofluorimetric method has been developed for the determination of some selected sulfhydryl-containing drugs namely Acetylcysteine (ACS), Captopril (CAP) and Mesna (MSN).The method is based on the interaction of the drugs with potassium (5-sulfoxino) palladium II in alkaline medium in presence of magnesium ions, where the sulfhydryl group combines with palladium from the non-fluorescent potassium bis (5-sulfoxino) palladium II. The resulting 8-hydroxy-5-quinoline sulfonic acid coordinates with magnesium to form the fluorescent chelate that is a measure of the amount of sulfhydrl containing drug analyzed. The fluorescence intensity was measured at an emission wavelength of 485 nm, by excitation at 345 nm. All the experimental parameters affecting the reaction were studied and optimized. The proposed method was applicable over the concentration range of 0.04-0.44 µg/mL for the three drugs and was applied for their determination in bulk form and in pharmaceutical preparations without interference from common excipients. The assay results were statistically compared with those obtained from previously reported methods where no significant difference was found between them. The selectivity and the stability-indicating aspect of the proposed method were confirmed by preparing the disulphides of the studied drugs and applying the reaction to the parent drugs in presence of their disulphides where no interference was detected from these related substances. By virtue of its high sensitivity, the proposed method was also extended to analyze the drugs in spiked human plasma and urine.

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“…To determine captopril or its metabolites in blood or plasma, several analytical methods have been described including HPLC with UV and fluorescence detection [6][7][8][9][10], liquid chromatographymass spectrometry (LC-MS), liquid chromatography tandem mass spectrometry (LC-MS/MS) [11][12][13][14], gas chromatography-mass spectrometry (GC-MS) [15,16], radioimmunoassay (RIA) [6] and enzyme immunoassay [6] with the HPLC methods most widely investigated. Although the analytical literature seems abundant for the determination of captopril in human blood or plasma, a method using standard analytical equipment providing a sensitive and simple micro-analytical method for determining captopril from a small blood volume has not been addressed and was therefore investigated in the present study.…”

Section: Introductionmentioning

confidence: 99%

Captopril Determination in Dried Blood Spot Samples with LC-MS and LCHRMS: A Potential Method for Neonate Pharmacokinetic Studies

Lawson¹,

Mulla²,

Tanna³

2012

J Bioanal Biomed

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A selective and rapid method for the quantification of captopril in human plasma using liquid chromatography/selected reaction monitoring mass spectrometry

Cited by 39 publications

References 12 publications

A Liquid Chromatography/Tandem Mass Spectrometric Method for Determination of Captopril in Human Plasma: Application to a Bioequivalence Study

A Liquid Chromatography/Tandem Mass Spectrometric Method for Determination of Captopril in Human Plasma: Application to a Bioequivalence Study

Spectrofluorimetric Estimation of Some Sulfhydryl–Containing Drugs by Demasking Reaction of the Palladium Chelate of 8-Hydroxyquinoline-5-Sulfonic Acid

Captopril Determination in Dried Blood Spot Samples with LC-MS and LCHRMS: A Potential Method for Neonate Pharmacokinetic Studies

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