Weed control during the establishment year of switchgrass (Panicum virgatum L.) is critical for a successful stand. Laboratory and field studies were conducted for 2 yr to evaluate the effectiveness of seed safeners for protecting switchgrass seed from the preemergent herbicide metolachlor. Initial evaluations of six seed safeners determined that fluxofenim was the only successful protectant tested for switchgrass seedling germination. Safener rates 0, 25, 50, and 100% of the recommended rate (40 mg a.i. 100 g per seed), method of application (coating vs. controlled hydration), ecotype (lowland vs. upland), dry matter yield, and number of crowns per row were analyzed in replicated field trials conducted in Starkville, MS, Ames, IA, Blacksburg, VA, and Brookings, SD, in a randomized complete block design. Two establishment years were planted in single‐row (6.1 m) plots spaced 50.8 cm apart. Subsequent biomass yield was harvested at the end of each growing season. Exceptional stands were achieved with all rates of safener in both years due to the reduction or elimination of annual grassy weeds and no crop injury was experienced at any test location. The controlled hydration (combination of 25, 50, or 100% fluxofenim) method resulted in significantly greater yields and crown counts than the coating technique at most locations for both years.