A selective HIV-1 RNA G-quadruplex-targeting l-aptamer–d-antisense conjugate inhibits HIV-1 minus strand transfer

Abstract

Herein, we develop a new l-RNA aptamer, l-Apt.T8, to target HIV-1 U3-III RNA G-quadruplex. The click-generated l-aptamer–d-antisense conjugate (l-Apt.T8-10D) can improve target binding performance and inhibit in vitro HIV-1 minus strand transfer.