A selective LSPR biosensor for molecular-level glycated albumin detection

Advances in flame synthesis of nano-scale architectures for chemical, biomolecular, plasmonic, and light sensing

“…The research suggested that this biosensor could enhance diabetes diagnosis, particularly when used alongside standard glucose monitoring methods. 136 This study highlights the potential of this novel biosensor for practical applications, offering a rapid and inexpensive method for enhanced diabetes diagnosis.…”

“…The sensor's DNA aptamer conjugation selectively binds to GA, inducing a plasmonic wavelength shift, allowing for a detection limit of 0.1 μM, which falls well within the human GA range of 20–240 μM. 136 The biosensor demonstrated its capability to provide mean glucose levels over a three-week period, correlating with the glycation status of diabetes patients. Selectivity experiments conducted with various molecules confirmed the sensor's specificity, and tests for sensor reusability yielded positive results.…”

“…In another study, 136 a biosensor designed to detect glycated albumin (GA), an important biomarker for diabetes monitoring, was developed using a novel approach 114. This biosensor utilizes localized surface plasmon resonance (LSPR) for signal transduction, achieved through a fabrication process involving the deposition of gold nanoparticles on a quartz substrate using FSP.…”