A selective near-infrared fluorescent probe for singlet oxygen in living cells

Xu, Kehua; Wang, Lulu; Qiang, Mingming; Wang, Liyong; Li, Ping; Tang, Bo

doi:10.1039/c1cc12473k

Cited by 92 publications

(55 citation statements)

References 27 publications

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“…[84] However,t he interference of ONOO À cannot be ruled out, as the fluorescence response of NIR-H 2 O 2 to ONOO À was not followed in this study.Atthe same time,various lipophilic cationic fluorescent probes (e.g.PTZ-Cy2 (31), [85] His-Cy (32), [86] Tr p-Cy (33); [87] Scheme 11) for other mitochondrial ROSwere also reported. [84] However,t he interference of ONOO À cannot be ruled out, as the fluorescence response of NIR-H 2 O 2 to ONOO À was not followed in this study.Atthe same time,various lipophilic cationic fluorescent probes (e.g.PTZ-Cy2 (31), [85] His-Cy (32), [86] Tr p-Cy (33); [87] Scheme 11) for other mitochondrial ROSwere also reported.…”

Section: Angewandte Chemiementioning

confidence: 97%

Discerning the Chemistry in Individual Organelles with Small‐Molecule Fluorescent Probes

et al. 2016

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Principle has it that even the most advanced super-resolution microscope would be futile in providing biological insight into subcellular matrices without well-designed fluorescent tags/probes. Developments in biology have increasingly been boosted by advances of chemistry, with one prominent example being small-molecule fluorescent probes that not only allow cellular-level imaging, but also subcellular imaging. A majority, if not all, of the chemical/biological events take place inside cellular organelles, and researchers have been shifting their attention towards these substructures with the help of fluorescence techniques. This Review summarizes the existing fluorescent probes that target chemical/biological events within a single organelle. More importantly, organelle-anchoring strategies are described and emphasized to inspire the design of new generations of fluorescent probes, before concluding with future prospects on the possible further development of chemical biology.

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Section: Angewandte Chemiementioning

confidence: 97%

Discerning the Chemistry in Individual Organelles with Small‐Molecule Fluorescent Probes

et al. 2016

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“…Lemp and co‐workers described naphthoxazole‐based fluorescent probes for the fluorescence “turn‐off” detection of 1 O 2 based on photooxidation reaction leading to the reformation of naphthoxazole entity, which could significantly increase the fluorescence. Another study reported a 1 O 2 probe based on the inhibition of the PET process for nonanthracene probes, which incorporated the amino acid, histidine (His), and anthocyanin. The probe was shown to detect endogenous 1 O 2 in RAW264.7 cells.…”

Section: Fluorescent Probes For the Detection Of Ros‐related Diseasesmentioning

confidence: 99%

Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

et al. 2019

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Reactive oxygen species (ROS) consist of a diverse range of oxidative small molecular ions and free radicals that are produced throughout the body during certain biological processes. Due to their high reactivity, these molecules result in the damage of tissues and cells. Therefore, ROS have been implicated in an array of diseases including cancer, inflammation, and neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Owing to the simplicity, sensitivity, and selectivity of fluorescence‐based strategies, many small‐molecular sensors or imaging agents have been developed to sense and visualize ROS both in vitro and in vivo. Likewise, activatable drug delivery and prodrug systems that can be triggered by ROS for disease theranostics (diagnostic and therapeutic combined) have been developed. Herein, recently developed fluorescence‐based sensing and imaging agents for the detection of ROS both intracellularly and in vivo are summarized. In addition, drug delivery, which require activation by ROS to achieve disease theranostics is also discussed.

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“…Over the years significant progress has been made towards detecting various metal ions (Dean et al, 2012; Penner-Hahn, 2013), including Zn 2+ (Carter et al, 2011; Guo et al, 2012; Radford et al, 2013; Wang et al, 2011; You et al, 2011), Na + (Schreiner and Rose, 2013), and K + (Padmawar et al, 2005). Probes were also developed for detecting small molecules such as NO (Dong et al, 2013; Yu et al, 2012), H + (pH probes) (Han and Burgess, 2010; Kim et al, 2013), singlet O 2 (Song et al, 2013; K. Xu et al, 2011), H 2 O 2 (Belousov et al, 2006; Guo et al, 2014), Cl - (Arosio and Ratto, 2014), large biomolecules such as matrix metalloproteinases (Vandenbroucke and Libert, 2014) and various biothiols (Xu et al, 2014), as well as complex cellular processes such as labeling dying cells with propidium iodide (Driscoll et al, 2011) or assessing the glutathione redox potential (Gutscher et al, 2008).…”

Section: Ca2+ and Other Cellular Functional Markersmentioning

confidence: 99%

High-resolution in vivo optical imaging of stroke injury and repair

Sakadžić¹,

Lee²,

Boas³

et al. 2015

Brain Research

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Central nervous system (CNS) function and dysfunction are best understood within a framework of interactions between neuronal, glial and vascular compartments comprising the neurovascular unit (NVU), all of which contribute to stroke-induced CNS injury, plasticity, repair, and recovery. Recent advances in in vivo optical microscopy have enabled us to observe and interrogate cells and their processes with high spatial resolution in real time and in their natural environment deep in the brain tissue. Here, we review some of these state-of-the-art imaging techniques with an emphasis on imaging the interactions among the constituents of the NVU during ischemic injury and repair in small animal models.

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A selective near-infrared fluorescent probe for singlet oxygen in living cells

Abstract: A selective near-infrared fluorescent probe (His-Cy), which features a fast response to (1)O(2) with high sensitivity and selectivity, was designed, synthesized and applied to bioimaging.

Cited by 92 publications

References 27 publications

Discerning the Chemistry in Individual Organelles with Small‐Molecule Fluorescent Probes

Discerning the Chemistry in Individual Organelles with Small‐Molecule Fluorescent Probes

Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

High-resolution in vivo optical imaging of stroke injury and repair

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