A Self‐Delivery Nanodrug Simultaneously Inhibits COX‐2/PGE2 Mediated Inflammation and Downregulates PD‐L1 to Boost Photoimmunotherapy
Jin‐Mei Lai,
Pei‐Ling Chen,
Qun‐Ying Shi
et al.
Abstract:Phototherapy promotes anti‐tumor immunity by inducing immunogenic cell death (ICD), However, the accompanying inflammatory responses also trigger immunosuppression, attenuating the efficacy of photo‐immunotherapy. Herein, they co‐assembled a cell‐membrane targeting chimeric peptide C16‐Cypate‐RRKK‐PEG8‐COOH (CCP) and anti‐inflammatory diclofenac (DA) to develop a nanodrug (CCP@DA) that both enhances the immune effect of phototherapy and weakens the inflammation‐mediated immunosuppression. CCP@DA achieves cell … Show more
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