A self-doping conductive polymer hydrogel that can restore electrical impulse propagation at myocardial infarct to prevent cardiac arrhythmia and preserve ventricular function

Zhang, Chongyu; Hsieh, Meng-Hsuan; Wu, Songyi; Li, Shuhong; Wu, Jun; Liu, Shiming; Wei, Hao-Ji; Weisel, Richard D.; Sung, Hsing‐Wen; Li, Ren‐Ke

doi:10.1016/j.biomaterials.2019.119672

Cited by 102 publications

(47 citation statements)

References 48 publications

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“…In this way, PG could be stimulated and electrically synchronised to AG under the influence of action potentials generated by the active group, as shown in Figure 3. Recent studies have confirmed that the conductive scaffold can decrease the resistivity of the fibrotic scar tissue in the infarcted region [25,[93][94][95]. In one of the studies, the Langendorff-perfused beating heart as the source of ionic current was placed on one side and a microelectrode array (MEA) was placed on the other side to measure the field potential amplitude, with a gelatin matrix cushion in the middle mimicking the inert scar tissue.…”

Section: The Underlying Mechanisms Of the Positive Role Of Conductive Substrates In Cardiac Tissue Engineeringmentioning

confidence: 99%

“…When injected with gelatin-hyperbranched poly(amino ester)/PPy hydrogels, the infarct size was reduced by 3.4-fold while LV wall thickness increased by 2.6-fold four weeks post-injection [74]. A new class of emerging conductive polymeric hydrogels made of poly-3-amino-4-methoxybenzoic acid/gelatin (PAMB-G) increased the electrical pulse propagation through scar tissue with a 1.6-fold increase in the conduction velocity [94]. When loaded with CMs, the PAMB-G patch reduced the scar resistivity evident from a 3.4-fold increase in the field potential.…”

Section: Conductive Substrates For In Vivo Cardiac Repairmentioning

confidence: 99%

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Intrinsically Conductive Polymers for Striated Cardiac Muscle Repair

Haq

Carotenuto

et al. 2021

IJMS

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One of the most important features of striated cardiac muscle is the excitability that turns on the excitation-contraction coupling cycle, resulting in the heart blood pumping function. The function of the heart pump may be impaired by events such as myocardial infarction, the consequence of coronary artery thrombosis due to blood clots or plaques. This results in the death of billions of cardiomyocytes, the formation of scar tissue, and consequently impaired contractility. A whole heart transplant remains the gold standard so far and the current pharmacological approaches tend to stop further myocardium deterioration, but this is not a long-term solution. Electrically conductive, scaffold-based cardiac tissue engineering provides a promising solution to repair the injured myocardium. The non-conductive component of the scaffold provides a biocompatible microenvironment to the cultured cells while the conductive component improves intercellular coupling as well as electrical signal propagation through the scar tissue when implanted at the infarcted site. The in vivo electrical coupling of the cells leads to a better regeneration of the infarcted myocardium, reducing arrhythmias, QRS/QT intervals, and scar size and promoting cardiac cell maturation. This review presents the emerging applications of intrinsically conductive polymers in cardiac tissue engineering to repair post-ischemic myocardial insult.

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Section: The Underlying Mechanisms Of the Positive Role Of Conductive Substrates In Cardiac Tissue Engineeringmentioning

confidence: 99%

Section: Conductive Substrates For In Vivo Cardiac Repairmentioning

confidence: 99%

Intrinsically Conductive Polymers for Striated Cardiac Muscle Repair

Haq

Carotenuto

et al. 2021

IJMS

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“…The sponge scaffold’s porosity was in the range of 88–95%, with the addition of biopolymers, such as alginate and chitosan, onto the collagen [ 56 ]. Moreover, injectable-electroconductive hydrogels have the potential to improve cell survival, which could be translated into a novel treatment protocol [ 29 , 42 , 57 ], while minimising the need for invasive surgery. Additionally, the incorporation of electroconductive nanomaterials in hydrogels may influence their bulk electrical properties and topography, which can also affect the retention and biology of living cells.…”

Section: Techniques In Fabricating Electrically Conductive Scaffoldsmentioning

confidence: 99%

Advocating Electrically Conductive Scaffolds with Low Immunogenicity for Biomedical Applications: A Review

et al. 2021

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Scaffolds support and promote the formation of new functional tissues through cellular interactions with living cells. Various types of scaffolds have found their way into biomedical science, particularly in tissue engineering. Scaffolds with a superior tissue regenerative capacity must be biocompatible and biodegradable, and must possess excellent functionality and bioactivity. The different polymers that are used in fabricating scaffolds can influence these parameters. Polysaccharide-based polymers, such as collagen and chitosan, exhibit exceptional biocompatibility and biodegradability, while the degradability of synthetic polymers can be improved using chemical modifications. However, these modifications require multiple steps of chemical reactions to be carried out, which could potentially compromise the end product’s biosafety. At present, conducting polymers, such as poly(3,4-ethylenedioxythiophene) poly(4-styrenesulfonate) (PEDOT: PSS), polyaniline, and polypyrrole, are often incorporated into matrix scaffolds to produce electrically conductive scaffold composites. However, this will reduce the biodegradability rate of scaffolds and, therefore, agitate their biocompatibility. This article discusses the current trends in fabricating electrically conductive scaffolds, and provides some insight regarding how their immunogenicity performance can be interlinked with their physical and biodegradability properties.

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“…Based on the produced color of fresh and fermented extract of red cabbage at different pH (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14), the color response of pH indicator gel was prepared by incorporating the fresh anthocyanin extract. The color response was determined by immersing the gel at different pH buffer solutions (pH 7.0-14.0).…”

Section: Color Responsementioning

confidence: 99%

“…The development of colorimetric indicator gels can also be mentioned as a smart hydrogel that can respond to stimuli (in this case, pH) and adapt to environmental conditions. Hydrogel has been utilized in various fields, e.g., medical purposes, agriculture, wound dressing, and water treatment [7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Multicolor PEGDA/LCNF Hydrogel in the Presence of Red Cabbage Anthocyanin Extract

Safitri

Mahendra

Putra

et al. 2021

Gels

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Colorimetric indicator gels were developed by incorporating anthocyanin (AC) obtained from red cabbage into poly (ethylene glycol) diacrylate (PEGDA)-based hydrogel containing lignocellulose nanofiber (LCNF). The PEGDA-based hydrogel was prepared by mixing all of the mentioned components at the specific composition, and the hydrogels were cured under UV light (245 nm) for 1 min. The pH-response, UV absorption, swelling ratio, and mechanical properties of PEGDA/LCNF were determined. It was further found that PEGDA and LCNF mount play an important role in adjusting the mechanical properties of PEGDA/LCNF. In general, the presence of LCNF improved the mechanical properties and swelling ratio of PEGDA. The incorporation of red cabbage anthocyanin into the PEGDA/LCNF film showed multicolor response when specific pH buffers were introduced. Based on the multicolor response of PEGDA/LCNF/CA, this gel film indicator can be developed as a food freshness indicator that focuses on the detection of ammonia and amine compound.

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A self-doping conductive polymer hydrogel that can restore electrical impulse propagation at myocardial infarct to prevent cardiac arrhythmia and preserve ventricular function

Cited by 102 publications

References 48 publications

Intrinsically Conductive Polymers for Striated Cardiac Muscle Repair

Intrinsically Conductive Polymers for Striated Cardiac Muscle Repair

Advocating Electrically Conductive Scaffolds with Low Immunogenicity for Biomedical Applications: A Review

Multicolor PEGDA/LCNF Hydrogel in the Presence of Red Cabbage Anthocyanin Extract

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