The integration of artificial intelligence (AI)-based robot therapy (AIBRT) has become prominent in addressing the needs of children with disabilities, including autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), learning disabilities, and speech delays. However, questions arise regarding the effectiveness of different AI techniques in enhancing therapy for children with specific needs. This review explores current literature on AIBRT for children with disabilities, aiming to understand the efficacy and potential of various AI techniques in improving their therapy. This paper presents a comprehensive search of research articles published from 2019 to September 2023. 39 articles focusing on AI-based robot platforms, the employed treatment or therapy methods, assessment procedures during therapy, and the variables or parameters used to measure intervention effectiveness have been discussed in detail. These AI-based robot platforms have been utilized to engage individuals diagnosed with ASD, offering therapeutic interventions and assessments. In conclusion, the integration of AI and robotics in therapy shows promise for enhancing the development and quality of life for children with disabilities. The findings of this review have implications for therapists, practitioners, and researchers interested in incorporating AI applications into therapy practices. This integration can lead to improved therapy outcomes, optimized children’s development, and enhanced quality of life.