T his wor k discusses the impact of W ake-Up Radio (W uR) technology to extend the battery life on sensor and actuator nodes in a smart home scenario. T he focus is on nodes that harvest energy from light or a temperature gradient and implement D ASH7, an open-source low-power protocol supporting both query-response and beaconing communication models. A prototype W uR is used, with a quiescent cur rent less than 1 µ A and a sensitivity of-38 dBm compatible with indoor applications. E xperimental data show that integrating W uR is not convenient in nodes that need to send a message to the networ k coordinator periodically, e.g. sensor nodes implementing beaconing communication models. O n the contrary, in request-response mode, integrating the W uR, the average actuator cur rent consumption reduces from 35 µ A down to 6 µ A during a reference period where no data or commands are exchanged between the networ k coordinator and the node. T hanks to the W uR, we find that an average light intensity of 150 lux throughout daytime and less than 14 min of a temperature gradient of 10°C between the hot and cold side of a thermoelectric generator are sufficient to turn the actuator nodes for water flooding and smart heating control into an energetically autonomous mode.