Light-emitting diodes (LEDs) are semiconductor devices that produce non-coherent, non-collimated, and narrow-spectrum lights (approximately 255-1300 nm) when a forward voltage is applied. 1,2 LED devices, including blue (420-440 nm), red (630-680 nm), and yellow (590-595 nm) LED lights, as well as near-infrared (LED-NIR; 750-1200 nm), are typically applied in five fields, including indicators and signs, lighting, data communication, machine vision systems, and especially, biological applications. 2 In fact, the application of LEDs in dermatology has really attracted the attention of dermatologists and estheticians thanks to their ideal properties (photobiomodulation [PBM] reactions) as well as outstanding advantages (e.g., high compliance, convenience, simplicity, and painlessness). 2,3 In fact, a number of studies have demonstrated the benefits of LEDs in various clinical practices, such as accelerating wound healing, inhibiting infection, rejuvenating skin, treating acne and atopic dermatitis, radiation therapy, and photodynamic therapy (PDT). [3][4][5][6][7] Specifically, LEDs have been popularly integrated into PDT devices as light sources to treat a wide range of medical conditions (e.g., cancer, acne, psoriasis, atherosclerosis, and anti-viral treatments). 4 The principle of treatment is based on PBM reactions, which include