A self-targeting and controllable drug delivery system constituting mesoporous silica nanoparticles fabricated with a multi-stimuli responsive chitosan-based thin film layer

Chen, Chao; Yao, Wei; Sun, Wen; Guo, Tianyuan; Lv, Hangya; Wang, Xiaoli; Ying, Hanjie; Wang, Yibing; Wang, Ping

doi:10.1016/j.ijbiomac.2018.09.058

Cited by 67 publications

(32 citation statements)

References 47 publications

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“…The famous physicochemical properties of nanomaterials have attracted the attention of researchers in the fields of gas sensors [1], catalysis [2][3][4], energy production [5], medicine [6] and environmental protection [7]. These methods signify the importance of nanomaterials regarding the production of variety of products and better materials [8], such as cosmetics, clothing, computers, medical devices and sports equipment [9]. The transition metal oxides have been in the focus of researchers for several years, due to their basic properties as well as technological applications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization of V2O5 nanoparticles and determination of catalase mimetic activity by new colorimetric method

Rasheed

Mansoor

Abdullah

et al. 2020

J Therm Anal Calorim

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This paper deals with an advanced colorimetric method used to determine the catalase mimetic activity of V2O5 nanoparticles by measuring the decrease in potassium permanganate concentration in a mixture containing V2O5 and hydrogen peroxide. The experiments were carried out in batch reactor at room temperature for 3 min at wavelength number of 525 nm. Vanadium pentoxide was synthesized by hydrothermal method (reflux) from ammonium metavanadate (NH4VO3) as a precursor and cetyltrimethylammonium bromide as a surfactant. The annealing of the product was carried out for 2 h, at temperatures of 250, 500 and 750 °C. In order to determine the structure and the chemical nature of the nanoparticles prepared, the characterization was carried out by X-ray diffraction and scanning electron microscopic techniques. Atomic force microscopic and thermal gravimetric investigations have shown the decomposition steps of V2O5 at different temperatures. UV–visible spectroscopic technique and Fourier transform spectrometry were used to further characterize the nanoparticles. Advanced colorimetric method was used to study the catalase mimetic activity of the newly synthesized vanadium pentoxide (V2O5) nanoparticles using hydrogen peroxide (H2O2) as substrate. V2O5 nanoparticles resulted in an increase in the catalase mimetic activity with increasing the annealing temperature of the V2O5 nanoparticles. The maximum activity was found at 500 °C, which subsequently decreased with further increase in the annealing temperature.

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization of V2O5 nanoparticles and determination of catalase mimetic activity by new colorimetric method

Rasheed

Mansoor

Abdullah

et al. 2020

J Therm Anal Calorim

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“…The most used targeting element is folic acid (FA, vitamin B9), which show a well-known reactivity that permits its incorporation in highly complex systems like nanogates. For example, Cai reported the use of FA to modify a pH-sensitive In +3 -containing fluorescent chelate [84], while Qi and Wang reported two redox-sensitive models, based on FA-tagged cyclodextrins [85] and FA-modified dithiol-containing chitosan copolymer [86], respectively. Such is the relevance of FA that it is also employed as a reference targeting ligand, being an example the study that compared the drug delivery properties of two different mesostructures such as MCM-41 vs KCC-1 [87].…”

Section: Small Moleculesmentioning

confidence: 99%

Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery: an update

Castillo

Lozano

González

et al. 2019

Expert Opinion on Drug Delivery

145

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Introduction: Mesoporous silica nanoparticles (MSNs) are outstanding nanoplatforms for drug delivery. Herein, the most recent advances to turn MSN-based carriers into minimal side effect drug delivery agents are covered. Areas covered: This review summarizes the scientific advances dealing with MSNs for targeted and stimuli-responsive drug delivery since 2015. Delivery aspects to diseased tissues together with approaches to obtain smart MSNs able to respond to internal or external stimuli and their applications are here described. Special emphasis is done on the combination of two or more stimuli on the same nanoplatform and on combined drug therapy. Expert opinion: The use of MSNs in nanomedicine is a promising research field because they are outstanding platforms for treating different pathologies. This is possible thanks to their structural, chemical, physical and biological properties. However, there are certain issues that should be overcome to improve the suitability of MSNs for clinical applications. All materials must be properly characterized prior to their in vivo evaluation; furthermore, preclinical in vivo studies need to be standardized to demonstrate the MSNs clinical translation potential.

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“…Through the recognition of these receptors by targeting ligands on MSNs, more smart targeting strategies have been achieved. The targeting ligands now used for MSN-based HCC theranostics include lactobionic acid (Zhang et al, 2012), folic acid (Chen et al, 2019), arginine-glycine-aspartate (RGD) (Chen et al, 2012), transferring (Hao et al, 2017), hyaluronic acid (Lee et al, 2018), low-density lipoprotein (LDL) (Ao et al, 2018), and others ( Table 1).…”

Section: Active Targetingmentioning

confidence: 99%

“…It has been found that electrostatic interactions between the positively charged agents [such as doxorubicin (DOX)] and negatively charged MSNs were greatly reduced by protonation in a low pH condition, which results in a pHresponsive release of DOX (Chen et al, 2018). Similarly, some gatekeepers over the pore entrance to reduce premature release of agents could be protonated under acidic pH, rapidly collapsing, thus the agents would be released from the nanoparticles (Chen et al, 2019). Besides, some chemical bonds connecting the gatekeepers and MSNs, which would be broken down by pH stimulation, are also be used in pH-responsive release (Liu et al, 2016).…”

Section: Internal Stimulimentioning

confidence: 99%

“…et al, 2017;Jiang et al, 2017). Consequently, GSH-responsive become one of most popular redox-responsive precision delivery strategies because of the higher GSH level in intracellular matrix of HCC cells than that in extracellular matrix or intracellular matrix of normal Chen et al, 2010Chen et al, , 2019Gao B. et al, 2015;Lv et al, 2015;Wang Y. et al, 2016;Wang et al, 2017a,b; RGD Integrin SMMC-7721, HepG2, Huh7…”

Section: Internal Stimulimentioning

confidence: 99%

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Emerging and Innovative Theranostic Approaches for Mesoporous Silica Nanoparticles in Hepatocellular Carcinoma: Current Status and Advances

Tao

Wang

2020

Front. Bioeng. Biotechnol.

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Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal solid cancers globally. To improve diagnosis sensitivities and treatment efficacies, the development of new theranostic nanoplatforms for efficient HCC management is urgently needed. In the past decade, mesoporous silica nanoparticles (MSNs) with tailored structure, large surface area, high agents loading volume, abundant chemistry functionality, acceptable biocompatibility have received more and more attention in HCC theranostic. This review outlines the recent advances in MSNs-based systems for HCC therapy and diagnosis. The multifunctional hybrid nanostructures that have both of therapy and diagnosis abilities are highlighted. And the precision delivery strategies of MSNs in HCC are also discussed. Final, we conclude with our personal perspectives on the future development and challenges of MSNs.

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A self-targeting and controllable drug delivery system constituting mesoporous silica nanoparticles fabricated with a multi-stimuli responsive chitosan-based thin film layer

Cited by 67 publications

References 47 publications

Synthesis, characterization of V2O5 nanoparticles and determination of catalase mimetic activity by new colorimetric method

Synthesis, characterization of V2O5 nanoparticles and determination of catalase mimetic activity by new colorimetric method

Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery: an update

Emerging and Innovative Theranostic Approaches for Mesoporous Silica Nanoparticles in Hepatocellular Carcinoma: Current Status and Advances

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