A Sensitive Analytical Apparatus for Measuring Hydrogen Production Rates. II. Application to Studies in Human Infants

Stevenson, David K.; Cohen, Ronald S.; Ostrander, Clinton R.; Shahin, Susan; Kerner, John A.; Wetmore, Donna L.; Werner, Sheri B.; Tomczyk, Marilyn; Johnson, John D.

doi:10.1097/00005176-198201020-00014

Cited by 14 publications

(14 citation statements)

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“…One study (17) , comparing a nasal prong collection technique with the Haldane-Priestly technique, found a good correlation coefficient (r = 0.94) between these two techniques for sampling end-tidal gas concentrations, with the values obtained by the nasal prong technique being slightly higher than those obtained via the Haldane-Priestly tube technique. However, both MacLean and Fink (29) and Stevenson et al (30) reported that the nasal prong technique yielded consistently lower Hz concentrations than those obtained by oropharyngeal or nasopharyngeal catheters. Both nasal prong and nasopharyngeal catheter breath collection techniques have been compared to simultaneous determinations of Hz excretion rate (30).…”

Section: Collection Techniquesmentioning

confidence: 96%

“…Despite the simple and straightforward nature of the method , investigators and clinicians have been presented with a myriad of expressions for quantifying breath H 2 • This is related mostly to the different breath collection techniques employed. When breath samples are obtained via rebreathing systems (10,12,14,18,21) or continuous flowthrough apparatuses (30), breath H 2 is quantified in terms of excretion rate in units of volume divided by time (ml/min, ml/h , rnl/rnin/kg, etc.). When the collection technique is based on either whole breath (16,27) or end-tidal (15,17,19 ,20) volume fractions, breath H 2 is quantified in terms of concentration units which are typically expressed as ppm, p,I/L, or p,mollL.…”

Section: Standardization Of Breath H 2 Analysismentioning

confidence: 99%

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Breath Hydrogen Analysis

Ostrander,

Cohen,

Hopper

et al. 1983

J. pediatr. gastroenterol. nutr.

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Summary:Hydrogen gas (H2) is a product of the fermentation of dietary carbohydrate (CHO) by bacteria in the lumen of the gastrointestinal tract in man. Thus, H2 is actually an exogenously produced gas, which either is passed as flatus, or diffuses into the body and is exhaled. In the adult, a fairly constant fraction is expired, providing a reliable indicator of total colonic H2 production. Breath H2 analysis currently represents a useful clinical means of testing adults and older children for the malabsorption of CHO. Noninvasive and easy procedures for the collection of expired air have encouraged their increasingly widespread use in pediatrics. Evidence to date suggests that breath H2 analysis may provide the best available method for estimating semiquantitatively the degree of CHO malabsorption. The association of the results of breath H2 analysis with other clinical measures of CHO digestion and absorption is expected, but discrepancies can also be anticipated based on the nature of this particular trace gas method. The interpretation of the results of breath H2 analysis in neonates and young infants remains especially problematic because of confounding variables which are difficult to control and are measured infrequently.

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Section: Collection Techniquesmentioning

confidence: 96%

Section: Standardization Of Breath H 2 Analysismentioning

confidence: 99%

Breath Hydrogen Analysis

Ostrander,

Cohen,

Hopper

et al. 1983

J. pediatr. gastroenterol. nutr.

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“…Methods and instruments to sample alveolar air are based on devices that allow dead-space air to be separated and discarded while the remaining end-expiratory (alveolar) air is collected in a gas-tight bag. Methods that have been used in children include face masks [146,147], rebreathing bags [148], nasal prong [149], and oropharyngeal or nasopharyngeal catheters [150,151]. In younger (noncollaborative) children, exhaled air can be collected using a face-mask connected to a double bag by means of a T-valve [152].…”

Section: H 2 -Breath Test: Principles and Proceduresmentioning

confidence: 99%

Breath tests in pediatrics

Anania

Pacifico

Olivero

et al. 2008

Clinica Chimica Acta

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“…Breath hydrogen tests were undertaken in five children as described previously [13]. Following an overnight fast and collection of a baseline breath sample, lactulose (1 g/kg) was given orally and breath samples collected for 3 h thereafter at 30 min intervals.…”

Section: Lactulose Breath Hydrogen Testmentioning

confidence: 99%

The use of metronidazole in management of methylmalonic and propionic acidaemias

Thompson¹,

Chalmers²,

Walter³

et al. 1990

Eur J Pediatr

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Gut bacteria have been implicated as an important source of propionate in children with inborn errors of propionate metabolism. We have investigated the value of oral metronidazole (10-20 mg/kg per day) in five children with methylmalonic acidaemia (MMA) and four with propionic acidaemia (PA). Urinary excretion of propionate metabolites fell significantly during the treatment in all subjects, the mean decrease being 41% (range 12-76, P less than 0.01), while mean plasma propionate was reduced from 45.0 mumol/l to 25.1 mumol/l (P less than 0.05). Substantial reduction of the gut bacterial population was confirmed by lactulose breath hydrogen tests and by stool culture, and stool propionate concentration was reduced in most subjects. Clinical improvement was noted in three children. These results suggest that long-term antimicrobial therapy may offer significant clinical benefit to children with inborn errors of propionate metabolism.

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A Sensitive Analytical Apparatus for Measuring Hydrogen Production Rates. II. Application to Studies in Human Infants

Cited by 14 publications

References 0 publications

Breath Hydrogen Analysis

Breath Hydrogen Analysis

Breath tests in pediatrics

The use of metronidazole in management of methylmalonic and propionic acidaemias

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