A sensitive chromatographic determination of hydrazines by naphthalene-2,3-dialdehyde derivatization

Simple and sensitive determination of hydrazine in drinking water by ultra-high-performance liquid chromatography–tandem mass spectrometry after derivatization with naphthalene-2,3-dialdehyde

“…In comparison to other methods, the LOD was similar to values obtained by GC-MS [27], GC-MS/MS [28] and LC-MS/MS [36] that required solid phase microextraction or liquid-liquid extraction and concentration, as described in Table 2. As observed, the LOD of the proposed method was approximately 15 times lower than those of the methods using HPLC after derivatization with NDA [34,35] even though the proposed method employed a very small sample and injection volume.…”

“…The NDA reaction conditions with hydrazine were very similar to the pH values [24,34,35], reaction temperatures and times [34,35] employed in previous studies. …”

“…In particular, the reaction with propyl chloroformate [28] results in three products (i.e., bi-, tri-, and tetra-derivatives), which make the quantification of hydrazine challenging. HPLC methods also require derivatization reagents, such as 4-chloro-5,7-dinitrobenzofurazan [20,31], cinnamaldehyde [29], benzaldehyde [30], and naphthalene-2,3-dialdehyde (NDA) [32][33][34][35]. The most sensitive HPLC method for the determination of hydrazine in water involves the fluorescent derivatization of hydrazine with NDA [32][33][34][35], which yields a hydrazine detection limit of 0.05 g/L.…”

“…GC methods for hydrazine have been developed using electron capture detection [21], nitrogen-selective detection [22,23], flame-ionization detection [24], mass spectrometry (MS) [23,[25][26][27], and tandem mass spectrometry (MS/MS) [19,28]. HPLC methods have also been developed using diode array detection [20,[29][30][31] and fluorescence detection [32][33][34][35]. Both the GC and LC methods require a derivatization step for the sensitive detection of hydrazine.…”

A Natural Light Visible Colorimetric Responses Fluorescent Probe for Hydrazine Detection

“…9 To date, there are several analytical methods for hydrazine detection, such as SERS, 10 electrochemical methods, 11,12 titration, 13 gas chromatography, 14 ultraviolet spectrometry, 15 and HPLC. 16 A simple and rapid method for hydrazine detection is still urgently needed. A fluorescent probe is an analytical tool, which meets this requirement.…”