A sensitive electrochemical method for the determination of 5-hydroxytryptophan in rats' brain tissue based on a carbon nanosheets-modified electrode

Abstract

In this paper, a novel electrochemical method is proposed for the determination of 5-hydroxytryptophan (5-HTP) based on a carbon nanosheets (CNSs)-modified electrode.

5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology

“…Their high sensitivity and miniaturization are expected to overcome the shortcomings of high-cost, time-consuming, and complicated operations linked to chromatographic methods. Various types of surface-modified electrodes have been developed to determine 5-HTP such as a carbon nanosheet-modified electrode [ 41 ], Ru II terpyridine-doped composite electrode [ 42 ], gold-modified pencil graphite electrode [ 43 ], graphene-chitosan molecularly imprinted film modified on the surface of a glassy carbon electrode [ 44 ], sensors based on electro-polymerization to obtain a poly-(melamine)/poly-(o-aminophenol) co-polymeric film [ 45 ], nano-palladium decorated multi-walled carbon nanotubes [ 46 ], citrate-capped gold nanoparticles [ 47 ], a pyrolytic graphite electrode with the surface covered with a thin film of a nano-mixture of graphite/diamond [ 48 ], and by electrochemical microfluidic separation and sensing [ 49 ].…”