A sensitive electrochemical platform integrated with a 3D graphene aerogel for point-of-care testing for tumor markers

Hu, Tao; Wu, Zihao; Wen, Shuguang; Ding, Bo; Chen, Ke; Li, Xiao; Shen, Yang; Zhang, Ni

doi:10.1039/d2tb00846g

Cited by 7 publications

(7 citation statements)

References 29 publications

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“… This can be further proved by IR spectral results. It is well established that strong characteristic IR absorption peaks of GO appear at 1730 cm –1 (ν CO ), 1620 cm –1 (ν O–H ), 1582 cm –1 (ν CC ), and 1143 cm –1 (ν COH ), respectively . In the IR spectra of rGO and 1 @rGO, the absorption peaks at 1582 cm –1 (ν CC ) and 1620 cm –1 (ν O–H ) are maintained, and the absorption peaks at 1730 cm –1 (ν CO ) and 1143 cm –1 (ν COH ) become weak.…”

Section: Resultsmentioning

confidence: 97%

An Innovative Sb^III–W^VI-Cotemplated Antimonotungstate with Potential in Sensing Paroxetine Electrochemically

Sun,

Xie,

Tang

et al. 2024

Inorg. Chem.

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Advances in polyoxometalate (POM) self-assembly chemistry are always accompanied by new developments in molecular blocks. The exploration and discovery of uncommon building blocks offer great possibilities for generating unprecedented POM clusters. An intriguing SbIII–WVI-cotemplated antimonotungstate [H2N(CH3)2]11Na[SbW9O33]Er2(H2O)2Sb2[SbWVIW15O57]·22H2O (1) was synthesized, which comprises a classical trivacant Keggin [SbW9O33]9– ({SbW9}) fragment and an unclassical lacunary Dawson-like [SbWVIW15O57]15– ({SbWVIW15}) subunit. Notably, the Dawson-like {SbWVIW15} subunit is the first example of a [SbO3]3– and [WVIO6]6– mixed-heteroatom-directing POM segment. Hexacoordinated [WVIO6]6– can not only serve as the heteroatom function but its additional oxygen sites can also link to lanthanide, main-group metal, and transition-metal centers to form the innovative structure. {SbWVIW15} and {SbW9} subunits are joined by the heterometallic [Er2(H2O)2Sb2O17]22– cluster to give rise to an asymmetric sandwich-type architecture. To further realize its potential application in electrochemical sensing, a conductive 1@rGO composite was obtained by the electrochemical deposition of 1 with graphene oxide (GO). Using a 1@rGO-modified glassy carbon electrode as the working electrode, an electrochemical biosensor for detecting the antidepressant drug paroxetine (PRX) was successfully constructed. This work can provide a viable strategy for synthesizing mixed-heteroatom-directing POMs and demonstrates the application of POM-based materials for the electrochemical detection of drug molecules.

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Section: Resultsmentioning

confidence: 97%

An Innovative Sb^III–W^VI-Cotemplated Antimonotungstate with Potential in Sensing Paroxetine Electrochemically

Sun,

Xie,

Tang

et al. 2024

Inorg. Chem.

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“…The limit of detection (LOD) is calculated as 0.419 pg mL –1 through the ratio of detection peak current to 3.3δ Table S2 displays the comparison of the method with other existing methods for electrochemical analysis of CEA, suggesting the satisfactory sensitivity of the method with a lower LOD. − For each concentration of CEA, the electrochemical analysis has been repeated at least three times and the average value of relative standard deviations (RSDs) is only 3.68%, indicating good reproducibility of the method. Furthermore, experiments have been conducted to prove the specificity of the method by using other tumor-associated glycoprotein biomarkers (e.g., MUC1, AFP, PD-L1, and PDGF-BB) and 10% diluted serum containing complex amounts of glycosylated substances as the controls.…”

Section: Resultsmentioning

confidence: 97%

Proximity Amplification-Enabled Electrochemical Analysis of Tumor-Associated Glycoprotein Biomarkers

Yu,

Cao,

Zhao

et al. 2023

Anal. Chem.

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Glycoproteins produced and secreted from specific cells and tissues are associated with several diseases and emerge as typical biomarkers to provide useful information in cancer diagnosis considering their abnormal expression levels. In this work, we design a universal method to achieve the accurate and sensitive analysis of tumor-associated glycoprotein biomarkers based on both carbohydrate recognition and protein recognition at the same protein surface. The byproduct of dual recognition-induced proximity amplification, pyrophosphate, triggers the disassembly of methylene blue-encapsulated metal−organic frameworks, MB@ZIF-90. As a result, methylene blue molecules are released to arouse amplified electrochemical responses for glycoprotein analysis. Experimental results demonstrate the high-accuracy analysis of carcinoembryonic antigen, a typical glycoprotein biomarker in cancer diagnosis, in a linear range of 0.001−100 ng mL −1 with a low limit of detection of 0.419 pg mL −1 . The method also displays satisfactory specificity and recoveries in complex serum samples and proves good versatility by adopting two other tumor-associated glycoprotein biomarkers, α-fetoprotein and mucin-1, as the targets. Therefore, this work provides a valuable tool for the analysis of glycoprotein biomarkers, which may be of great potential in early warning of malignant tumors in clinical applications.

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“…The results demonstrated that the composed sandwich-type immunoassay protocol performed suitable reproducibility, high sensitivity, good precision, and resistance. 1.0 × 10 −8 -1.0 × 10 −5 mg mL −1 7.9 pg mL −1 [134] Graphene aerogel microspheres Folic acid (FA) and octadecylamine (OA)-functionalized graphene aerogel microspheres (FA-GAM-OA)…”

Section: Antibodies-based Biosensormentioning

confidence: 99%

“…The 3D-GA was prepared via in situ chemical reduction of graphene oxide with Lascorbic acid and then dehydration by freeze-drying by Hu et al [134]. After the modification of the 3D-GA, they were be used for detecting various tumor markers in liquid samples via electrochemical impedance spectroscopy (EIS).…”

Section: Prostate Specific Antigenmentioning

confidence: 99%

Trends on Aerogel-Based Biosensors for Medical Applications: An Overview

Almeida,

Merillas,

Pontinha

2024

IJMS

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Aerogels are unique solid-state materials composed of interconnected 3D solid networks and a large number of air-filled pores. This structure leads to extended structural characteristics as well as physicochemical properties of the nanoscale building blocks to macroscale, and integrated typical features of aerogels, such as high porosity, large surface area, and low density, with specific properties of the various constituents. Due to their combination of excellent properties, aerogels attract much interest in various applications, ranging from medicine to construction. In recent decades, their potential was exploited in many aerogels’ materials, either organic, inorganic or hybrid. Considerable research efforts in recent years have been devoted to the development of aerogel-based biosensors and encouraging accomplishments have been achieved. In this work, recent (2018–2023) and ground-breaking advances in the preparation, classification, and physicochemical properties of aerogels and their sensing applications are presented. Different types of biosensors in which aerogels play a fundamental role are being explored and are collected in this manuscript. Moreover, the current challenges and some perspectives for the development of high-performance aerogel-based biosensors are summarized.

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A sensitive electrochemical platform integrated with a 3D graphene aerogel for point-of-care testing for tumor markers

Abstract: Point-of-care testing (POCT) of tumor markers, such as alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA), can be used for the early diagnosis of cancer. In this paper, a highly sensitive electrochemical...

Cited by 7 publications

References 29 publications

An Innovative Sb^III–W^VI-Cotemplated Antimonotungstate with Potential in Sensing Paroxetine Electrochemically

An Innovative Sb^III–W^VI-Cotemplated Antimonotungstate with Potential in Sensing Paroxetine Electrochemically

Proximity Amplification-Enabled Electrochemical Analysis of Tumor-Associated Glycoprotein Biomarkers

Trends on Aerogel-Based Biosensors for Medical Applications: An Overview

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A sensitive electrochemical platform integrated with a 3D graphene aerogel for point-of-care testing for tumor markers

Abstract: Point-of-care testing (POCT) of tumor markers, such as alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA), can be used for the early diagnosis of cancer. In this paper, a highly sensitive electrochemical...

Cited by 7 publications

References 29 publications

An Innovative SbIII–WVI-Cotemplated Antimonotungstate with Potential in Sensing Paroxetine Electrochemically

An Innovative SbIII–WVI-Cotemplated Antimonotungstate with Potential in Sensing Paroxetine Electrochemically

Proximity Amplification-Enabled Electrochemical Analysis of Tumor-Associated Glycoprotein Biomarkers

Trends on Aerogel-Based Biosensors for Medical Applications: An Overview

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An Innovative Sb^III–W^VI-Cotemplated Antimonotungstate with Potential in Sensing Paroxetine Electrochemically

An Innovative Sb^III–W^VI-Cotemplated Antimonotungstate with Potential in Sensing Paroxetine Electrochemically