A sensitive LC–MS/MS method for analysis of pericyazine in presence of 7-hydroxypericyazine and pericyazine sulphoxide in human plasma and its application to a comparative bioequivalence study in Chinese healthy volunteers

Cai, Hua Lin; Deng, Yang; Fang, Ping; Cao, Sisi; Hou, Zhen Yan; Wu, Yang-feng; Chen, Xue Jiao; Yan, Miao; Zhang, Bikui

doi:10.1016/j.jpba.2016.12.007

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…Although the toxic range of periciazine has not been described, this patient's blood levels were not significantly different from those of a normal adult male receiving 10 mg of periciazine (10). However, her return to consciousness coincided with the decrease in blood concentration of periciazine, suggesting that periciazine toxicity contributed to her symptoms.…”

Section: Discussionmentioning

confidence: 54%

“…Her overall condition also improved. Although periciazine has a long half-life of approximately 8 h, its peak concentration is achieved at 1.8 h, after which the concentration starts to decline (10). Considering this, the α-receptor antagonist effect of periciazine likely waned as its concentration decreased, rendering the patient more responsive to antihypertensive agents, yielding gradual circulatory improvement.…”

Section: Discussionmentioning

confidence: 99%

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Polypharmacy-related Shock Symptoms and Complications Associated with Phenothiazine

Nakamura,

Masuda,

Oda

et al. 2024

Intern. Med.

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This report describes a case of shock symptoms in a 72-year-old woman with epilepsy who had been in a state of polypharmacy, taking multiple antipsychotic drugs. After receiving a normal dose of periciazine, she exhibited impaired consciousness, hypothermia, and hypotension and was admitted to hospital. Despite poor response to vasopressors, conservative treatment led to gradual improvement. Subsequent pharmacokinetic analysis showed non-toxic blood concentrations of periciazine, suggesting that even small doses of phenothiazines could result in toxic symptoms. This case highlights the importance of monitoring for adverse reactions when prescribing multiple antipsychotic drugs, particularly in older polypharmacy patients.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Polypharmacy-related Shock Symptoms and Complications Associated with Phenothiazine

Nakamura,

Masuda,

Oda

et al. 2024

Intern. Med.

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A new oxidative derivatization method for spectrophotometric determination of Periciazine in pharmaceutical preparations

Blazheyevskіy¹,

Moroz

2019

Fr. Ukr. J. Chem.

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A new the oxidative derivatization method by means of peroxoacid for the indirect spectrophotometric determination of Periciazine is presented. A potassium hydrogenperoxymonosulfateas a derivatizing agent for Periciazine, yielding the absorbative Periciazine sulfoxide at λmaх=362 nm is proposed. This reaction product was successfully employed for spectrophotometric determination of the Periciazine. The UV spectrophotometric determination of the Periciazine as its sulfoxide proved to be the more simple and selective method. Limit of quantification (LOQ=10S) is 2.8 µg·mL-1. The common excipients employed do not interfere in the determination of phenothiazine drug. Results of analysis of the drug dosage forms by the proposed method are in good agreement with those of the official method. RSD=1.76 % (δ <RSD).

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The Oxidative Derivatization Method For The Spectrofluorimetric Determination Of Periciazine In Pharmaceutical Preparations

Blazheyevskіy

Scrypynets

Yegorova

et al. 2020

MOCA

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The oxidative derivatization method for the indirect spectrofluorimetric determination of Periciazine has been presented. Potassium hydrogenperoxymonosulfate (Oxone ®) is proposed as a derivatizing agent for Periciazine, yielding the strongly fluorescent Periciazine sulfoxide. A highly sensitive, simple and rapid method for determination of the Periciazine by fluorescence of its oxidation product with Oxone ® solution in 0.02 M hydrochloric acid solution (λex = 364 nm; λem = 444 nm) has been developed. The calibration plot is linear in concentration range of 0.05 – 4.00 µg mL -1 . LOQ (10S) is 0.05 µg mL -1 . The possibility of quantitative determination of Periciazine in pharmaceutical preparations (Neuleptil ®, 10 mg capsules and Neuleptil ®, a 30 mL 4 % oral (solution) drops) has been shown RSD < 2.2 % (δ < RSD).

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A sensitive LC–MS/MS method for analysis of pericyazine in presence of 7-hydroxypericyazine and pericyazine sulphoxide in human plasma and its application to a comparative bioequivalence study in Chinese healthy volunteers

Cited by 4 publications

References 16 publications

Polypharmacy-related Shock Symptoms and Complications Associated with Phenothiazine

Polypharmacy-related Shock Symptoms and Complications Associated with Phenothiazine

A new oxidative derivatization method for spectrophotometric determination of Periciazine in pharmaceutical preparations

The Oxidative Derivatization Method For The Spectrofluorimetric Determination Of Periciazine In Pharmaceutical Preparations

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