2014
DOI: 10.1002/bmc.3302
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A sensitive LC‐MS/MS method for quantifying capsaicin and dihydrocapsaicin in rabbit plasma and tissue: application to a pharmacokinetic study

Abstract: Prescription and nonprescription products for topical management of pain, including cream, lotion and patch forms, contain capsaicin (CAP) and dihydrocapsaicin (DHC). There are few in vivo studies on absorption, bioavailability and disposition of CAP and DHC. We established a sensitive and rapid LC-MS/MS assay to determine CAP and DHC levels in rabbit plasma and tissue. Bio-samples prepared by liquid-liquid extraction using n-hexane-dichloromethane-isopropanol (100: 50: 5, v/v/v) mixture were separated by isoc… Show more

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Cited by 12 publications
(9 citation statements)
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“…Several analytical techniques have been applied for the analysis of capsaicinoids, including gas chromatography [5] and liquid chromatography (LC), which has been by far the most widely preferred [6][7][8][9][10][11][12][13][14][15][16][17][18]. LC methods tend to use UV absorption spectrophotometry [6], fluorescence detection (FLD) [7][8][9], and mass spectrometry (MS) [10][11][12][13][14][15][16][17][18] as detection systems.…”
Section: Introductionmentioning
confidence: 99%
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“…Several analytical techniques have been applied for the analysis of capsaicinoids, including gas chromatography [5] and liquid chromatography (LC), which has been by far the most widely preferred [6][7][8][9][10][11][12][13][14][15][16][17][18]. LC methods tend to use UV absorption spectrophotometry [6], fluorescence detection (FLD) [7][8][9], and mass spectrometry (MS) [10][11][12][13][14][15][16][17][18] as detection systems.…”
Section: Introductionmentioning
confidence: 99%
“…Several analytical techniques have been applied for the analysis of capsaicinoids, including gas chromatography [5] and liquid chromatography (LC), which has been by far the most widely preferred [6][7][8][9][10][11][12][13][14][15][16][17][18]. LC methods tend to use UV absorption spectrophotometry [6], fluorescence detection (FLD) [7][8][9], and mass spectrometry (MS) [10][11][12][13][14][15][16][17][18] as detection systems. Among the different available MS analyzers, triple quadrupole (QqQ) MS [10,[12][13][14][15][16][17] and high-resolution MS (HRMS) based on time of flight [18] have been satisfactorily applied for this purpose.…”
Section: Introductionmentioning
confidence: 99%
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“…LC-MS/MS and HPLC methodology were reported for the determination of capsaicin in different applications such as liposomes, pellets [1618]. As far as we know, there were no reports about the collagen sponge capsaicin loaded.…”
Section: Introductionmentioning
confidence: 99%