A sensitive procedure for determination of morphine in mouse whole blood by high performance liquid chromatography with electrochemical detection.

Ito, Koichi; McGaugh, James L.; Shibanoki, Shinji; Kubo, Taizo

doi:10.1254/jjp.32.969

Cited by 11 publications

(1 citation statement)

References 4 publications

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“…23 This could be the result of shorter half-life of morphine (ϳ 42 minutes) in mice compared with humans (2-4 hours). 24 The cannabinoid receptor agonist, (-)-cis-3-[2-hydroxy-4(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl) cyclohexanol (CP 55940; Tocris Bioscience) was prepared in 5% emulphor, 5% ethanol, and 90% normal saline. Separate groups of HbA-BERK, BERK, and hBERK1 mice received 0.3 mg/kg CP 55940 intraperitoneally in a volume of 0.1 mL/10 g body weight.…”

Section: Drugs and Their Usementioning

confidence: 99%

Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids

Kohli

Khasabov

et al. 2010

Blood

167

298

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Sickle cell disease causes severe pain. We examined pain-related behaviors, correlative neurochemical changes, and analgesic effects of morphine and cannabinoids in transgenic mice expressing human sickle hemoglobin (HbS). Paw withdrawal threshold and withdrawal latency (to mechanical and thermal stimuli, respectively) and grip force were lower in homozygous and hemizygous Berkley mice (BERK and hBERK1 ,

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Section: Drugs and Their Usementioning

confidence: 99%

Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids

Kohli

Khasabov

et al. 2010

Blood

167

298

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Histamine turnover in the brain of morphine-dependent mice

Oishi

Nishibori

Itoh

et al. 1988

Naunyn-Schmiedeberg's Arch Pharmacol

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The turnover of brain histamine was examined in mice implanted subcutaneously with a morphine pellet (50 mg free base). The numbers of naloxone-precipitated jumpings and body shakes were maximum 2 and 3 days after implantation, respectively. The brain tele-methylhistamine level significantly increased (50% to 115%) during 12 h-3 days after implantation of a morphine pellet, whereas the histamine level remained unchanged. The accumulation of tele-methylhistamine by pargyline treatment was significantly enhanced when pargyline was administered 12 h after implantation, suggesting an enhancement of histamine turnover. However, a similar degree of the tele-methylhistamine accumulation was induced by pargyline during 1-5 days after implantation, as compared with the accumulation in the control mice implanted with a placebo pellet. In mice undergoing morphine withdrawal by either the removal of morphine pellet or the treatment with naloxone 3 days after implantation, the degree of the pargyline-induced tele-methylhistamine accumulation or the (S)-alpha-fluoromethylhistidine (alpha-FMH)-induced histamine decrease was similar to that observed in the placebo pellet-control mice. The numbers of naloxone-precipitated jumpings and body shakes occurring in mice 3 days after implantation were not significantly affected by any of L-histidine, alpha-FMH or metoprine. These results suggest that turnover of histamine in the brain is enhanced by acute morphine treatment and returns to the normal rate in the stage of chronic treatment and remains unchanged during the state of withdrawal.

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Direct correlation between level of morphine and its biochemical effect on monoamine systems in mouse brain

Ito

Shibanoki

McGaugh

1983

Biochemical Pharmacology

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A sensitive procedure for determination of morphine in mouse whole blood by high performance liquid chromatography with electrochemical detection.

Cited by 11 publications

References 4 publications

Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids

Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids

Histamine turnover in the brain of morphine-dependent mice

Direct correlation between level of morphine and its biochemical effect on monoamine systems in mouse brain

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