A sensitive sensor based on molecularly imprinted polypyrrole on reduced graphene oxide modified glassy carbon electrode for nevirapine analysis

Pour, Bayazid Hassan; Haghnazari, Nahid; Keshavarzi, Fatemeh; Ahmadi, Elham; Zarif, Bahareh Rahimian

doi:10.1039/d1ay00500f

Cited by 13 publications

(6 citation statements)

References 40 publications

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“…The negative linear shift of E a p from 1.200 to 0.850 V with increasing pH was also observed as shown in Fig. 5B resulting in two Nernstian ranges [10,62,63] over pH 5-9 and 10-12 with slopes of 60.1 and 33.7 mV⋅decade − 1 , respectively (Fig. 5C and D).…”

Section: Effect Of Ph On the Electrochemical Behaviour Of Efv At Cuc/...supporting

confidence: 59%

Copper-Modified Carbon Nano-Onions as Electrode Modifiers for the Electroanalysis of the Antiretroviral Drug Efavirenz

Mokwebo

Murphy

Guin

et al. 2023

Preprint

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Section: Effect Of Ph On the Electrochemical Behaviour Of Efv At Cuc/...supporting

confidence: 59%

Copper-Modified Carbon Nano-Onions as Electrode Modifiers for the Electroanalysis of the Antiretroviral Drug Efavirenz

Mokwebo

Murphy

Guin

et al. 2023

Preprint

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“…The size distribution data also suggests that nanoparticles are formed and can be seen in the highlighted area. Further, the polymerization was confirmed by the rougher surface compared to silanized GO (Pour et al, 2021). The difference in morphology between silanized GO and MIP‐GO composite confirms the successful formation of the MIP layer on the surface of silanized GO.…”

Section: Resultsmentioning

confidence: 94%

“…The surface morphology of the synthesized material was examined by SEM. Figure 6a,b shows SEM images of silanized GO, and it shows the sheet‐like structure with lamella (Pour et al, 2021). However, after polymerization was done, Figure 6c,d clearly shows that silanized GO was covered with nanoparticles and microparticles ranging from 2 to 20 μm that verify the polymerization was successfully achieved on the surface of the silanized GO (Huang et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

Development of a molecularly imprinted polymer on silanized graphene oxide for the detection of 17‐estradiol in wastewater

Mughal,

Aylaz,

Shaikh

et al. 2024

Water Environment Research

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This research article demonstrates the synthesis, characterization, and electrochemical evaluation of a molecularly imprinted polymer (MIP) on the surface of silanized graphene oxide (silanized GO), which is nanostructured and used to quantify 17‐estradiol (E2) in wastewater. As characterization methods, X‐ray diffraction (XRD), Raman spectroscopy, dynamic scattering light (DSL), scanning electron microscope (SEM), and Fourier transform infrared spectroscopy (FTIR) were utilized to examine the synthesized GO, silanized GO, MIP‐GO composite, and non‐imprinted polymer (NIP)–GO (NIP‐GO) composite. FTIR results confirmed the successful synthesis of GO composites. Raman study confirmed the synthesis of monolayer silanized GO, MIP‐GO composite, and NIP‐GO composite. Surface morphology revealed that after polymerization, the surface of silanized GO sheet‐like morphology is covered with nanoparticles. Adsorption kinetics studies revealed that adsorption follows the pseudo‐second‐order kinetics. Further, we studied the performance of a MIP‐GO‐based sensor by optimizing the effects of pH, scan rate, and incubation period. The linear calibration was achieved between the oxidation peak current and E2 concentration from 0.1 to 0.81 ppm, with a detection limit of 0.037 ppm. The selectivity of the MIP‐GO composite was also checked by using other estrogens, and it was found that E2 is 3.3, 0.5, and 1.4 times more selective than equilin, estriol, and estrone, respectively. The composite was successfully applied to the wastewater samples for the detection of E2, and a good percentage of recoveries were achieved. It suggests that the reported composite can be applied to real samples.Practitioner Points An innovative electrochemical sensor was developed for selective detection of 17‐estradiol through molecularly imprinted polymer fabricated on the surface of silanized GO (MIP‐GO composite). The developed method was comprehensively validated and found to be linear in the range of 0.1 to 0.8 ppm of 17‐estradiol, with 0.037 ppm of limit of detection and 0.1 ppm of limit of quantification, respectively. The developed MIP‐GO‐composite‐based electrochemical sensor was found 3.3, 0.5, and 1.4 times more selective for 17‐estradiol than equiline, estriol, and estrone, respectively. The applicability of a developed sensor was also checked on wastewater samples, and a good percent recovery was obtained.

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“…The electrolytes used for the experiment were 2.0 × 10 −3 mol l −1 NaOH with linearity over the range 0.01-0.14 ppm and a LOD of 3 nM were estimated from detection of 0.02 ppm after a 6 min accumulation. The proposed modified and unmodified sensors comparing their detection limits reported in literature for NVP detection are shown in Table II 33 showed a higher limit of detection and concentration range than other reported sensors followed by HgF. 44 Although the best results were found in HgF but due to its toxicity, this kind of sensor has been discontinued.…”

Section: Electrochemical Detection Of Nevirapine (Nvp)mentioning

confidence: 94%

“…GCE/MIP/ErGO.-Recently, a molecular imprinting polymer (MIP) sensor was fabricated by Pour and co-workers to develop the electro-polymerization of pyrrole (Py) on electrochemically reduced graphene oxide (ErGO) immobilized on a glassy carbon electrode (GCE) and successfully used for NVP analysis. 33 The NVP measurements were tested using DPV in an alkaline medium under optimized environment. The DPV signal of NVP increased linearly with concentration the range of 0.005 μM and 400 μM and was highly stable for an extended period.…”

Section: Electrochemical Detection Of Nevirapine (Nvp)mentioning

confidence: 99%

Review—Nanostructured Electrochemical Sensors for Determination of the First Generation of the NNRTIs for HIV-1

Silwana

Matoetoe²

2022

ECS Adv.

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Since the 1980s, the HIV/AIDS pandemic has been a global concern and remains despite the tremendous efforts and successes in the development of antiviral drugs. The drug development and formulation process are not without challenges. However, the effective use of excipients can allow formulators to circumvent or at least minimize the impact of these challenges. Some of the challenges include ensuring a high quality of actives, free from impurities, and ensuring administration in appropriate quantities. Incorrect dosing can have a detrimental impact on the body. Evaluation of the quality and physiological function of these drugs in pharmaceutical and biological samples is vital. We explore the application of electrochemical methods for the detection of these drugs. Electrochemical methods are versatile and cheaper in comparison to conventional techniques. This review paper provides the latest developments and new trends in electroanalysis of the first generation of nonnucleoside reverse transcriptase inhibitors drugs. Furthermore, we highlight several phenomena occurring on bare solid electrodes and modified electrodes, including underlying mechanisms. Recent data shows that modified electrodes based on nanoparticles present substantial advantages over their non-modified counterparts enabling portability, higher selectivity, and multiple detection capabilities. These characteristics make nanoparticles promising candidates for the design of sensors.

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A sensitive sensor based on molecularly imprinted polypyrrole on reduced graphene oxide modified glassy carbon electrode for nevirapine analysis

Abstract: A molecularly imprinted polymer (MIP) sensor was offered for nevirapine (NVP) analysis based on the electropolymerization of pyrrole (Py) on electrochemically reduced graphene oxide (ErGO) immobilized on a glassy carbon electrode (GCE).

Cited by 13 publications

References 40 publications

Copper-Modified Carbon Nano-Onions as Electrode Modifiers for the Electroanalysis of the Antiretroviral Drug Efavirenz

Copper-Modified Carbon Nano-Onions as Electrode Modifiers for the Electroanalysis of the Antiretroviral Drug Efavirenz

Development of a molecularly imprinted polymer on silanized graphene oxide for the detection of 17‐estradiol in wastewater

Review—Nanostructured Electrochemical Sensors for Determination of the First Generation of the NNRTIs for HIV-1

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