The number of migrants increases globally due to natural disasters, global warming, and war conflicts. Inefficient and unsustainable construction approaches for migrant shelters have resulted from improper planning and design systems regarding lifespan, materials and techniques, and socio-cultural aspects. Therefore, the study aim has an incentive to assess the impact of the morphological, siting, and layout of zones and shelters for the long-term displacement prototypes considering sustainability concepts from social context, affordability, adaptability, low-impact construction materials, and techniques. Furthermore, applying the dynamic simulation IDA ICE 4.8 tool was cardinal to justify the comprehensive reported outcomes based on the bottom-up construction method after assessing energy and thermal comfort performance in seven cases. The energy performance assessment regarding heating reveals the superiority of the compact layout plan system, while the open-layout plan system is superior for electric cooling assessment. Concerning thermal comfort performance for the number of accepted hours category, the open-layout plan system is superior. Fanger indicators for thermal comfort assessment demonstrated the superiority of the horizontal-compact layout plan scheme. The carbon dioxide (CO2) concentration level assessment shows that the open-yard layout cases have better results than other systems. To conclude, sustainable prototypes for displaced people should involve several aspects such as lifespan, socio-cultural and affordability, thermal performance and energy-efficient, and environmental impact. The beneficiaries from the methods and the results of this study would be firstly the Syrian refugees in the Middle East context, then various places and involved people affected by the displacement issue globally.