2018
DOI: 10.1523/jneurosci.1467-18.2018
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A Sensorimotor Pathway via Higher-Order Thalamus

Abstract: We now know that sensory processing in cortex occurs not only via direct communication between primary to secondary areas, but also via their parallel cortico-thalamo-cortical (i.e., trans-thalamic) pathways. Both corticocortical and trans-thalamic pathways mainly signal through glutamatergic class 1 (driver) synapses, which have robust and efficient synaptic dynamics suited for the transfer of information such as receptive field properties, suggesting the importance of class 1 synapses in feedforward, hierarc… Show more

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Cited by 102 publications
(95 citation statements)
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“…As a result, mitochondria-rich synapses are capable of maintaining a high release probability over a wide range of firing rates 34 . Our observations of larger mitochondrial concentration near the VPM S1 synapses seems thus consistent with electrophysiological evidence that VPM synapses produce relatively large (∼4.8mV) excitatory postsynaptic potentials 9 or currents 10 with low failure rates 11, 12 , while Po synapses in S1-L5a produce smaller postsynaptic currents 10, 15, 16 , that have slower rise and decay times 14 .…”
Section: Discussionsupporting
confidence: 89%
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“…As a result, mitochondria-rich synapses are capable of maintaining a high release probability over a wide range of firing rates 34 . Our observations of larger mitochondrial concentration near the VPM S1 synapses seems thus consistent with electrophysiological evidence that VPM synapses produce relatively large (∼4.8mV) excitatory postsynaptic potentials 9 or currents 10 with low failure rates 11, 12 , while Po synapses in S1-L5a produce smaller postsynaptic currents 10, 15, 16 , that have slower rise and decay times 14 .…”
Section: Discussionsupporting
confidence: 89%
“…7; Table 1), despite the fact that these two synapse populations arise from different thalamic nuclei and are located in widely separated cortical domains. Such overall resemblance is consistent with electrophysiological observations that both Po MC and VPM S1 synapses elicit similarly large EPSCs 9, 16 , exhibit paired-pulse depression and involve only ionotropic receptors 3, 16 . Remarkably, however, the size of the Po MC-L3/4 synapse PSDs is 60% larger than that of the VPM L4 synapses, suggesting that the former may have even greater high synaptic strength and release probability.…”
Section: Discussionsupporting
confidence: 87%
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