A serial functional connectivity MRI study in healthy individuals assessing the variability of connectivity measures: reduced interhemispheric connectivity in the motor network during continuous performance

Amann, Michael; Hirsch, Jochen G.; Gass, Achim

doi:10.1016/j.mri.2009.05.016

Cited by 20 publications

(16 citation statements)

References 32 publications

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“…Additionally, we cannot state that all of our results are specific to evoked deep-tissue pain, as we did not evaluate how, for example, a non-painful somatosensory stimulation modulates functional brain connectivity. However, previous studies applying fcMRI during non-painful sensorimotor tasks [1; 52] did not report altered connectivity outside of primary and secondary sensorimotor regions. Finally, after the 6-minute PAIN scan, subjects were asked to rate pain over 3 different temporal windows – a procedure that may have required greater cognitive effort than rating pain for a single shorter-duration stimulus provocation.…”

Section: Discussionmentioning

confidence: 85%

“…For instance, reduction in left-right S1/M1 synchrony was found during unilateral continuous performance of a finger tapping task [2; 48; 53]. Contralateral somatotopic M1 connectivity to mid-cingulate and insula was not reported by these studies, and this connectivity may prove to be more pronounced during tasks with arguably greater salience to the organism, such as evoked pain.…”

Section: Discussionmentioning

confidence: 94%

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Sustained deep-tissue pain alters functional brain connectivity

Kim

Loggia

Edwards

et al. 2013

Pain

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Recent functional brain connectivity studies have contributed to our understanding of the neurocircuitry supporting pain perception. However, evoked-pain connectivity studies have employed cutaneous and/or brief stimuli, which induce sensations that differ appreciably from the clinical pain experience. Sustained myofascial pain evoked by pressure cuff affords an excellent opportunity to evaluate functional connectivity change to more clinically-relevant sustained deep-tissue pain. Connectivity in specific networks known to be modulated by evoked pain (sensorimotor, salience, dorsal attention, fronto-parietal control and default mode networks; SMN, SLN, DAN, FCN and DMN) was evaluated with functional-connectivity MRI, both at rest and during a sustained (6-minute) pain state in healthy adults. We found that pain was stable with no significant changes of subjects’ pain ratings over the stimulation period. Sustained pain reduced connectivity between the SMN and the contralateral leg primary sensorimotor (S1/M1) representation. Such SMN-S1/M1 connectivity decreases were also accompanied by and correlated with increased SLN-S1/M1 connectivity, suggesting recruitment of activated S1/M1 from SMN to SLN. Sustained pain also increased DAN connectivity to pain processing regions such as mid-cingulate cortex, posterior insula and putamen. Moreover, greater connectivity during pain between contralateral S1/M1 and posterior insula, thalamus, putamen, and amygdala, was associated with lower cuff pressures needed to reach the targeted pain sensation. These results demonstrate that sustained pain disrupts resting S1/M1 connectivity by shifting it to a network known to process stimulus salience. Furthermore, increased connectivity between S1/M1 and both sensory and affective processing areas may be an important contribution to inter-individual differences in pain sensitivity.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 94%

Sustained deep-tissue pain alters functional brain connectivity

Kim

Loggia

Edwards

et al. 2013

Pain

View full text Add to dashboard Cite

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“…It has been reported that the connectivity of the motor cortex becomes more unilateral during task performance [14]. However, when feedback was present, the connectivity became more bilateral, as seen in figures 2 and 3.…”

Section: Discussionmentioning

confidence: 91%

Real time BOLD functional MRI neuro-feedback affects functional connectivity

Horovitz

Berman

Hallett

2010

2010 Annual International Conference of the IEEE Engineering in Medicine and Biology

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Functional connectivity in the resting state based on BOLD functional MRI (fMRI) has been used mainly to observe brain networks while subjects ‘do nothing’. The same principle, however, can be used for any other steady-state brain condition. In this study, we compared the connectivity of the motor area during simple finger tapping with and without real time neuro-feedback of the activation in the hand motor area. The presence of the neuro-feedback not only induces correlations between the visual and motor areas, but also increases basal ganglia involvement and bilateral motor cortex connectivity.

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“…Resting state fluctuations in BOLD fMRI time-series have been increasingly employed to study functional connectivity networks in healthy brain and in disease (Buckner et al, 2008;Fox and Raichle, 2007;Greicius, 2008;Williamson, 2007). Functional connectivity MRI (fcMRI) studies have been conducted under a number of different conditions: resting eyes open (Fox et al, 2005;Van Dijk et al, 2010;Yan et al, 2009), eyes closed (Fox et al, 2005;Greicius et al, 2009;Van Dijk et al, 2010;Yan et al, 2009), visual fixation (Buckner et al, 2009;Fox et al, 2005;Van Dijk et al, 2010;Yan et al, 2009), focal visual stimulation (Bianciardi et al, 2009a), viewing pictures with positive, negative or neutral valences (Anand et al, 2005), finger tapping (Morgan and Price, 2004), continuous performance tasks (Amann et al, 2009), tactile stimulation (Mantini et al, 2009) and acupuncture (Hui et al, 2009). A number of recent studies have explicitly studied the state dependence of different functional connectivity networks (Bianciardi et al, 2009a;Fransson, 2006;Hampson et al, 2002;Newton et al, 2007;Van Dijk et al, 2010;Yan et al, 2009).…”

Section: Introductionmentioning

confidence: 99%