A Serial Study of Anticardiolipin Antibody and Antimitochondrial Antibody Type M5 in a Patient With Polyarthritis and Polymyositis

Keane, A.; Woods, R. J.; Foley-Nolan, D.; Roden, Denise A.; Coughlan, Robert J.; Barry, Chris

doi:10.1093/rheumatology/28.2.158

Cited by 5 publications

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“…6 So far, the clinical significance of AMA M5 was evaluated in only seven studies [1][2][3][4][5][6][7] and few reports describe isolated cases. [15][16][17][18] Even rare, the question is: if AMA M5 are present, how often they remain undetected? There are several potential causes that disable detection of AMA M5.…”

Section: Discussionmentioning

confidence: 99%

Clinical and serological follow-up of 71 patients with anti-mitochondrial type 5 antibodies

Andrejević¹,

Bonaci-Nikolic²,

Sefik-Bukilica³

et al. 2007

Lupus

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Antimitochondrial M5 type antibodies (AMA M5) have been described in patients with antiphospholipid syndrome (APS), thrombocytopenia and autoimmune hemolytic anemia. The aim of this study was to describe the clinical and immunological characteristics of a series of patients with AMA M5. We analyzed 71 patients with AMA M5 seen consecutively at our centres during the last 8 years. The clinical and immunological characteristics of diseases expression were compared with 70 consecutive disease control patients without AMA M5. Compared with the control group, AMA M5 positive patients presented higher prevalence of false positive VDRL test (P < 0.001) and thrombocytopenia (P = 0.002) with lower levels of anti-beta2 glycoprotein I antibodies. In AMA M5 patients (56 female, 15 male) a heterogeneous group of disorders were found. Twenty-seven (38%) patients fulfilled the Sapporo criteria for the classification of the APS. Laboratory criteria were met in 55 (77.5%), and clinical criteria in 31 (43.7%) patients. Six patients initially presented with non-criteria features of APS during follow-up period developed APS. Younger patients with AMA M5 should be carefully observed for the development of APS, even in the absence of serological criteria, while elderly must be screened for monoclonal gammopathy and hematological disorders.

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Section: Discussionmentioning

confidence: 99%

Clinical and serological follow-up of 71 patients with anti-mitochondrial type 5 antibodies

Andrejević¹,

Bonaci-Nikolic²,

Sefik-Bukilica³

et al. 2007

Lupus

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Involvement of mitochondria in myasthenia gravis complicated with dermatomyositis and rheumatoid arthritis: a case report

et al. 2005

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We report a 57-year-old male with myasthenia gravis complicated with dermatomyositis and rheumatoid arthritis without evidence of thymoma. He showed prominent muscle wasting and weakness in the four extremities and trunk in addition to swallowing disturbance. He showed intolerance to exercise on a bicycle ergometer, and muscle biopsy specimens demonstrated ragged-red fibers. An anti-acetylcholine receptor (AChR) antibody was detected in his serum but no anti-mitochondrial M2 component antibody was found. In contrast, results of immunohistochemical study indicated that his serum sample reacted to muscle mitochondria as well as AChR. These results indicate the presence of an unidentified anti-mitochondrial antibody that may be involved in the development of mitochondrial dysfunction in skeletal muscle of the present patient.

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Antiphospholipid antibodies: Lupus anticoagulant and anticardiolipin antibody

Petri

1992

Current Problems in Dermatology

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A Serial Study of Anticardiolipin Antibody and Antimitochondrial Antibody Type M5 in a Patient With Polyarthritis and Polymyositis

Cited by 5 publications

References 0 publications

Clinical and serological follow-up of 71 patients with anti-mitochondrial type 5 antibodies

Clinical and serological follow-up of 71 patients with anti-mitochondrial type 5 antibodies

Involvement of mitochondria in myasthenia gravis complicated with dermatomyositis and rheumatoid arthritis: a case report

Antiphospholipid antibodies: Lupus anticoagulant and anticardiolipin antibody

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