A series of critically challenging case scenarios in moderate to severe psoriasis: A Delphi consensus approach

Comorbidities significantly impact patients’ preferences for psoriasis treatments

“…Indeed, these patients are at higher risk of adverse effects when receiving systemic antipsoriatic therapy. 40,41 For example, treatment with acitretin may lead to hyperlipidemia; cyclosporine may evoke hypertension and renal insufficiency; and tumor necrosis factorea antagonists may worsen cardiac insufficiency. If prescribing systemic antipsoriatic medications for patients with cardiovascular disease, physicians should carefully address patients' concern and fear of side effects.…”

A consensus approach to improving patient adherence and persistence with topical treatment for actinic keratosis

“…Facilitators categorized the topics generating consensus into themes and issues that were then shared with the participants to confirm that they accurately represented the issues discussed. Issues within themes and emerging critical issues were prioritized using Likert scales, as used in previous consensus studies in dermatology 20,21,23,24. Our experts ranked issues using a six-point Likert scale (1 = least important, 6 = most important).…”

The Skin and Viral Liver Disease

“…Furthermore, clinical trials typically involve healthy patients or, at least, not 'difficult-to-treat' cases. In this regard, an inadequate representation in case populations of subjects with some relevant covariates, such as pediatric or elderly age, pregnancy or breastfeeding, history of kidney or liver disease, cancer, HIV, HBV and HCV infection, has been consistently documented [139][140][141]. Taken as a whole, these circumstances dictate extreme caution in extrapolating results to the broader population of patients in day-to-day clinical practice.…”

“…Nevertheless, treatment of HCV infected psoriasis populations is subject to the same caution expressed by current guidelines for the management of patients who are chronic carriers of HBV [134]. Concerning this aspect, two different authority panels have recently audited all pros and cons, and drawn up a ranking list each of therapeutic options for treatment of moderate-to-severe psoriasis in HCV patients (Tables 8.A and B) [139,172].…”