A series of pH and time dependent POM-based compounds by using a double chelate ligand: Syntheses, structures and electrochemical properties

Ying, Jun; Yu, Haiyan; Liu, Guiying; Fu, Yubo; Tian, Aixiang

doi:10.1016/j.inoche.2019.107626

Cited by 8 publications

(1 citation statement)

References 17 publications

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“…In this regard, the reactants (POMs, metal ions, and organic ligands) must be carefully chosen when constructing inorganic–organic hybrids based on POMs. Also, the structures of these hybrids are extremely dependent on the synthesis conditions like the molar ratio of the starting materials, pH, temperature, and time of the reaction due to the high sensitivity of POMs and coordination modes of ligands toward these factors. − …”

Section: Introductionmentioning

confidence: 99%

Anticancer Drug Extraction from Plasma Samples Using Three-Dimensional Polyoxometalate-Based Supramolecular Frameworks as Sorbents

Khoshkhan,

Mirzaei,

Amiri

et al. 2024

Inorg. Chem.

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Four self-assembled inorganic−organic hybrid materials, namely, H{Na- 4) (pydc−OH = 4-hydroxy-2,6-pyridinedicarboxylate), were hydrothermally synthesized and structurally characterized. Hybrids 1−3 are isostructural and contain a Keggin unit, which is linked to lanthanoids to produce distinct trinuclear lanthanoid building blocks. The fragments are connected by anion−π and hydrogen bonding interactions to create 3D networks. In hybrid 4, a trimeric Pr-organic species bearing a Keggin unit forms a 2D coordination polymer, and then hydrogen bonding interactions between 2D layers lead to the formation of a 3D structure. These polyoxometalate-based frameworks were used as sorbents for the dispersive microsolidphase extraction (D-μSPE) of two anticancer drugs (doxorubicin and epirubicin) in human plasma samples. Analytes were quantified and separated using high-performance liquid chromatography with fluorescence detection (HPLC-FLD). The method's linearity was between 0.8−500 ng mL −1 and 1.0− 500 ng mL −1 for the antineoplastic drugs doxorubicin and epirubicin, respectively. The limits of detection (S/N = 3) were in the range of 0.2−0.3 ng mL −1 , while the precision was in the range of 3.5−4.3%. Finally, human plasma samples from patients treated with doxorubicin or epirubicin were analyzed by using the D-μSPE-HPLC-FLD method.

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