A series of sensitive and visible fluorescence-turn-on probes for CMC of ionic surfactants: Design, synthesis, structure influence on CMC and sensitivity, and fast detection via a plate reader and a UV light

Cai, Xiaotie; Yang, Weijie; Huang, Lan; Zhu, Qiuhua; Liu, Shuwen

doi:10.1016/j.snb.2015.04.126

Cited by 38 publications

(24 citation statements)

References 27 publications

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“…AIE characteristic, found and termed by Tang's group [19], resolves the thorny aggregation-caused quenching problem of conventional fluorophores and has shown great advantages in wide areas [20], such as AIEgens-containing copolymers and their applications [21][22][23][24][25]. The characteristics of THPscompletely no emission in surfactant micelles but strong AIE in dilute surfactant solutions-let us develop them as unique sensitive and visible fluorescence-turn-on (showing the strongest fluorescence at CMC) probes for CMC (the reported CMC probes based on fluorescence intensity change show fluorescence-turn-off change at CMC, that is, show the weakest fluorescence at CMC) [26,27]. Recently, we found that one of the THPs could be used as an excellent indicator for CMC titration and realized simple, sample-and time-saving CMC titration for different kinds of surfactants for the first time [28].…”

Section: Introductionmentioning

confidence: 99%

Influence factors on the critical micelle concentration determination using pyrene as a probe and a simple method of preparing samples

Liang

et al. 2020

R. Soc. open sci.

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Zhu Q. 2020 Influence factors on the critical micelle concentration determination using pyrene as a probe and a simple method of preparing samples. R. Soc. open sci. 7: 192092. http://dx.The critical micelle concentration (CMC) is an important parameter of widely used surfactants and needs to be measured in the application and development of surfactants. Fluorometric method is a widely used method determining CMC values owing to the advantages of highly sensitivity, fast response and wide application range. There are two common methods (I and II) of preparing samples for CMC fluorometric determination. In the process of developing CMC probes with aggregation-induced emission (AIE) characteristics, we found that methods I and II were not suitable for CMC probes with AIE charateristics and developed a new sample preparation method (III), which is not only suitable for CMC probes with AIE characteristic but also decreases operation procedures and errors owing to omitting the addition of micro amount of dyes into each sample. To ascertain if method III is also suitable for other CMC probes without AIE characteristics, the CMC values of surfactants were determined by fluorometric method using widely used pyrene without AIE charateristic as probe and methods I-III to prepare samples. The obtained experimental results proved that method III not only was suitable for preparation of samples for CMC determination of surfactants using pyrene as probe but also led to the least average deviation (methods I-III led to ±0.13, ±0.34 and ±0.05 mM deviation for the CMC determination of sodium dodecyl sulfate (SDS), respectively). The CMC determination using pyrene as probe is based on its change in the ratio (I FIII /I FI ) of its emission peaks I and III with surfactant concentration. Unexpectedly, it was found that the I FIII /I FI value of pyrene in surfactant solutions is sensitive to the measurement conditions changing exciting light energy, such as slit widths and sample-measured number. In addition, it was found that surfactant SDS or cetrimonium bromide from different suppliers not only has significantly different CMC values but also leads to very different I FIII /I FI values of pyrene in a certain concentration of surfactant, which can be used as a simple method to distinguish the same surfactant with different CMC values.

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Section: Introductionmentioning

confidence: 99%

Influence factors on the critical micelle concentration determination using pyrene as a probe and a simple method of preparing samples

Liang

et al. 2020

R. Soc. open sci.

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“…As an ideal indicator for CMC titration, its signal change at CMC demands to be not only clearly visible but also sensitive and prompt. We screened these THPs reported in our previous work (Cai et al, 2015). Pleasantly and unexpectedly, THP-2 (Figure 2A) proved to be an excellent CMC titration indicator not only suitable for ionic surfactants but also suitable for nonionic surfactants (Figure 2C) (Wu et al, 2020).…”

Section: Frontiers Inmentioning

confidence: 99%

“…We found that THPs (for example, THPs 1-5 in Figure 2A) had no emission in ionic surfactant micelles but emit strong fluorescence in dilute ionic surfactant solutions (photos in Figure 2B). However, conventional fluorophores in micelles generally show stronger fluorescence intensity than fluorescence in (Zhu et al, 2014;Cai et al, 2015). Reproduced with permission from the Royal Society of Chemistry.…”

Section: Cmc Determination Based On the Characteristics Of Strong Aie In Surfactant Dilute Solutions But Non-emission In Surfactant Micelmentioning

confidence: 99%

“…surfactant solutions (Wandruszkav 1992). Based on the unusual characteristics of THPs in surfactant solutions, we developed THP-1 as a new type of fluorescence-turn-on probe for CMC determination of ionic surfactants (Zhu et al, 2014) and realized high-throughput CMC determination using highly sensitive THPs (Cai et al, 2015). The change in the fluorescence intensity of THPs near CMC is so sensitive that the change can be clearly observed by the naked eye.…”

Section: Cmc Determination Based On the Characteristics Of Strong Aie In Surfactant Dilute Solutions But Non-emission In Surfactant Micelmentioning

confidence: 99%

“…(B) Photos of THP-1 in surfactant solutions with concentration lower than or equal to critical micelle concentration (CMC) and higher than CMC, respectively. The emission spectra of THPs in different concentrations of surfactant solutions as well as the relationship between the fluorescence intensity of THPs at peak(Zhu et al, 2014;Cai et al, 2015). Reproduced with permission from the Royal Society of Chemistry.…”

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Optical Characteristics and Applications of AIE Racemic C6-Unsubstituted Tetrahydropyrimidines

Zhu

2021

Front. Chem.

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Racemic C6-unsubstituted tetrahydropyrimidines (THPs) are the products of an efficient five-component reaction that we developed. THPs show strong AIE characteristics, that is, completely no fluorescence in different solvents but strong emission with fluorescence quantum yields (ΦF) up to 100% upon aggregation. However, the ΦF values of their pure enantiomers are lower than 46%. Unlike common AIE compounds with crowded aryl rotors on a π-bond or on an aryl ring, THPs have three completely non-crowded aryl rotors on a non-aromatic chiral central ring (tetrahydropyrimidine). In this mini review, we first discuss the AIE characteristics of THPs and the influences of molecular structures on their molecular packing modes and optical properties, and then present their applications and forecast the development of other racemic AIE compounds.

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Accurate and sensitive probing of onset of micellization based on absolute aggregation‐caused quenching effect

Liu

Jiang

et al. 2022

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Probing the onset of micellization, or determining the critical micelle concentration (CMC), is of crucial importance while remains to be challenged by growing demand for extraordinary sensitivity and accuracy. Although fluorometry has attracted wide attention owing to its superiority in simplicity and sensitivity over other methods, the presence and fluctuation of background fluorescence of conventional fluorescent probes undermine the accuracy of CMC determination. Herein, a series of novel fluorescent probes without background fluorescence at a concentration below CMC owing to absolute aggregation‐caused quenching (aACQ) are utilized for sensitive and accurate measurement of CMC. The aACQ probes aggregate spontaneously and instantly in an aqueous environment owing to molecular π–π stacking with fluorescence quenching absolutely. Therefore, the absence of background fluorescence at a concentration below CMC clears relevant interference associated with conventional fluorophores. In this study, the new method is applied for versatile surfactants with CMCs ranging from nanomolar to millimolar concentrations, especially copolymers with ultralow CMC. The higher sensitivity and accuracy are highlighted by comparison with conventional probes.

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A series of sensitive and visible fluorescence-turn-on probes for CMC of ionic surfactants: Design, synthesis, structure influence on CMC and sensitivity, and fast detection via a plate reader and a UV light

Cited by 38 publications

References 27 publications

Influence factors on the critical micelle concentration determination using pyrene as a probe and a simple method of preparing samples

Influence factors on the critical micelle concentration determination using pyrene as a probe and a simple method of preparing samples

Optical Characteristics and Applications of AIE Racemic C6-Unsubstituted Tetrahydropyrimidines

Accurate and sensitive probing of onset of micellization based on absolute aggregation‐caused quenching effect

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