A Sero-Survey of Subtype H3 Influenza A Virus Infection in Dogs and Cats in Japan

Said, Awlad Wadair Ali; Usui, Tatsufumi; Shinya, Kyoko; Ono, Etsuro; Ito, Toshihiro; Hikasa, Yoshiaki; Matsuu, Aya; Takeuchi, Takashi; Sugiyama, Akihiko; Nishii, Naohito; Yamaguchi, Tsuyoshi

doi:10.1292/jvms.10-0428

Cited by 27 publications

(28 citation statements)

References 13 publications

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“…Furthermore, recent studies on the distribution of receptor molecules in the canine respiratory tract detected that SAα2,3Gal was the dominant receptor, although SAα2,6Gal could be detected in the trachea, bronchi and bronchioles. These reports are consistent with the hypothesis that the sero-positive dogs found in this study were infected with H 3 N 2 influenza A virus originating from human sources 13 .…”

Section: Resultssupporting

confidence: 93%

“…But the hemagglutination inhibition test is usually the choice for investigating the influenza virus 13,14 .…”

Section: Resultsmentioning

confidence: 99%

“…Their serum samples responded positively to human and equine influenza A viruses subtype H 3 in the hemagglutination inhibition test (HI) 13 .…”

Section: Resultsmentioning

confidence: 99%

“…They are considered to be intermediate hosts for the adaptation of avian influenza viruses to humans and "mixing vessels" for novel combinations between avian and human influenza viruses, which can result in the emergence of new pandemic strains. The resulting new viruses may then be able to infect horses and humans 13 . The proteolytic cleavage of the viral receptor proteins is also a very important activation mechanism in the pathogenesis of influenza viruses 18,20 .…”

Section: Introductionmentioning

confidence: 99%

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Influenza viruses in adult dogs raised in rural and urban areas in the state of São Paulo, Brazil

Mancini

Mendonça

Pereira

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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In 1970, searching for the interspecies transmission of influenza viruses led to the first study on influenza viruses in domestic animals. Birds and mammals, including human beings, are their natural hosts; however, other animals may also play a role in the virus epidemiology. The objective was to investigate the incidence of influenza viruses in adult dogs raised in rural (9, 19.56%) and urban (37, 80.43%) areas in the state of São Paulo, Brazil. Dog serum samples were examined for antibodies to influenza viruses by the hemagglutination inhibition (HI) test using the corresponding antigens from the circulating viruses in Brazil. Dogs from rural areas presented antibodies to influenza A H3N2, and influenza A H7N7 and H3N8. In rural areas, dog sera displayed mean titers as 94.37, 227.88, 168.14, 189.62 HIU/25 µL for subtypes H1N1, H3N2, H7N7, H3N8, respectively. About 84% and 92% of dogs from urban areas exhibited antibodies to human influenza A H1N1 and H3N2, respectively, with statistical difference at p < 0.05 between the mean titers of antibodies to H1N1 and H3N2. About 92% and 100% were positive for H7N7 and H3N8, respectively. In dogs from urban areas, the mean titers of antibodies against influenza A H1N1, H3N2, H7N7 and H3N8, were 213.96, 179.42, 231.76, 231.35 HIU/25 µL respectively. The difference among them was not statistically significant at p > 0.05. In conclusion, these dogs were positive for both human and equine influenza viruses. The present study suggests the first evidence that influenza viruses circulate among dogs in Brazil.

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Section: Resultssupporting

confidence: 93%

“…But the hemagglutination inhibition test is usually the choice for investigating the influenza virus 13,14 .…”

Section: Resultsmentioning

confidence: 99%

“…Their serum samples responded positively to human and equine influenza A viruses subtype H 3 in the hemagglutination inhibition test (HI) 13 .…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Influenza viruses in adult dogs raised in rural and urban areas in the state of São Paulo, Brazil

Mancini

Mendonça

Pereira

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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“…H3 subtype influenza viruses have been isolated from humans, pigs, horses, dogs, cats, seals, and numerous avian species (11)(12)(13)(14)(15)(16)(17)(18). Swine influenza viruses are prevalent in pigs worldwide.…”

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confidence: 99%

Replication and Immunogenicity of Swine, Equine, and Avian H3 Subtype Influenza Viruses in Mice and Ferrets

Baz

Paskel

Matsuoka

et al. 2013

J Virol

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Since it is difficult to predict which influenza virus subtype will cause an influenza pandemic, it is important to prepare influenza virus vaccines against different subtypes and evaluate the safety and immunogenicity of candidate vaccines in preclinical and clinical studies prior to a pandemic. In addition to infecting humans, H3 influenza viruses commonly infect pigs, horses, and avian species. We selected 11 swine, equine, and avian H3 influenza viruses and evaluated their kinetics of replication and ability to induce a broadly cross-reactive antibody response in mice and ferrets. The swine and equine viruses replicated well in the upper respiratory tract of mice. With the exception of one avian virus that replicated poorly in the lower respiratory tract, all of the viruses replicated in mouse lungs. In ferrets, all of the viruses replicated well in the upper respiratory tract, but the equine viruses replicated poorly in the lungs. Extrapulmonary spread was not observed in either mice or ferrets. No single virus elicited antibodies that cross-reacted with viruses from all three animal sources. Avian and equine H3 viruses elicited broadly cross-reactive antibodies against heterologous viruses isolated from the same or other species, but the swine viruses did not. We selected an equine and an avian H3 influenza virus for further development as vaccines.

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Canine influenza

Parrish

Dubovi

2016

Animal Influenza

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A Sero-Survey of Subtype H3 Influenza A Virus Infection in Dogs and Cats in Japan

Cited by 27 publications

References 13 publications

Influenza viruses in adult dogs raised in rural and urban areas in the state of São Paulo, Brazil

Influenza viruses in adult dogs raised in rural and urban areas in the state of São Paulo, Brazil

Replication and Immunogenicity of Swine, Equine, and Avian H3 Subtype Influenza Viruses in Mice and Ferrets

Canine influenza

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