A serological and molecular study on Francisella tularensis in rodents from Hamadan province, Western Iran

Hemati, Majid; Khalili, Mohammad; Rohani, Mahdi; Sadeghi, Balal; Esmaeili, Saber; Ghasemi, Ahmad; Mahmoudi, Ahmad; Gyuranecz, Miklós; Mostafavi, Ehsan

doi:10.1016/j.cimid.2019.101379

Cited by 8 publications

(6 citation statements)

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“…Rodents are natural hosts for F. tularensis and can carry live bacteria for an extended period while maintaining detectable antibody levels. Recently, there have been more reports of humans contracting tularemia from rodents [21]. However, information on the prevalence of tularemia in rodents in the Middle East is limited, with studies focusing mainly on Iran.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiology of tularemia in the countries of the WHO Eastern Mediterranean Region (EMRO): A systematic review and meta-analysis

Sholeh,

Moradkasani,

Esmaeili

2024

PLoS Negl Trop Dis

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Background Francisella tularensis, the bacterium that causes tularemia, has been a persistent and widespread pathogen in various regions of the world for centuries. Francisella tularensis can affect humans and various domestic and wild animals. The current study aimed to determine the epidemiological status of tularemia in countries of the WHO Eastern Mediterranean Region (EMRO) through a systematic review and meta-analysis. Methods All included studies were identified through a systematic search of online databases, including Scopus, PubMed, Web of Science, and EMBASE, through July 26, 2022, using keywords and suitable combinations. We focused on cross-sectional studies investigating the prevalence of F. tularensis. The weighted pooled prevalence was calculated using a random-effects model. Results A total of 206 studies were identified, of which 20 were finally included in the analysis. The human seroprevalence of tularemia in WHO-EMRO countries was 6.2% (95% CI, 4.2 9.2). In the subgroup analysis, anti-F. tularensis antibodies were found in 6.92% and 5.5% of the high-risk individuals and Iran, respectively. The pooled prevalence of F. tularensis in environmental samples (water and soil) from the WHO-EMRO countries was 5.8% (9.4% by PCR and 0.5% by culture). In addition, 2.5% (95% CI, 0.2 0.22.7) of ticks in WHO-EMRO countries were positive for F. tularensis. The pooled prevalence of F. tularensis in rodents is 2.0% (1.1% by PCR and 3.7% by serology). In addition, 0.6% of domestic ruminants (0.4% by PCR and 2.4% by serology) were positive for F. tularensis in WHO-EMRO countries. Conclusion According to the results of the present study, tularemia is an endemic but neglected disease in the WHO-EMRO region. However, most studies on tularemia are limited to a few countries in this region. Studies on tularemia in human populations, reservoirs, and vectors have been conducted in all countries in the WHO-EMRO region to obtain more detailed information about the epidemiology of tularemia in these regions.

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Section: Discussionmentioning

confidence: 99%

“…The title abstracts of the 96 articles were reviewed, 47 full-text articles were evaluated, and 27 articles were excluded. Eventually, this systematic review and meta-analysis included 20 eligible studies (Table 1) [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]…”

Section: Descriptive Statisticsmentioning

confidence: 99%

Epidemiology of tularemia in the countries of the WHO Eastern Mediterranean Region (EMRO): A systematic review and meta-analysis

Sholeh,

Moradkasani,

Esmaeili

2024

PLoS Negl Trop Dis

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“…Some interesting results are mentioned based on the studies conducted in connection with the epidemiology of the disease among human populations. For instance, different countries such as France, Spain, Slovakia, the Czech Republic, and Germany introduced hare hunting as the main cause of glandular infections [19] , [20] , [21] , [22] , [23] , [28] , [29] . Although serological and molecular studies conducted among different human societies in Iran show that some participants have specific clinical symptoms of tularemia, a large number of studies have shown that they are asymptomatic.…”

Section: Discussionmentioning

confidence: 99%

Francisella and tularemia in western Asia, Iran: a systematic review

Fooladfar

Moradi

2023

New Microbes and New Infections

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“…Exposure to wild and domestic animals expressing antibodies to F. tularensis were identified as a risk factor for humans in European parts of Turkey [38,39]. Rodents studied in western Iran (Hamadan Province) and belonging to species of the Persian jird (Meriones persicus) and Libyan jird (Meriones libycus) were tularemia-seropositive and showed no cross-reactivity with brucellosis [40]. Some Japanese wild animals, including black bears, were shown to be seropositive to F. tularensis antibodies [41,42].…”

Section: Interactions Of Hosts With Francisella In Nature Leave Significant Antibody Tracesmentioning

confidence: 99%

Francisella and Antibodies

Kubelková

Macela

2021

Microorganisms

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Immune responses to intracellular pathogens depend largely upon the activation of T helper type 1-dependent mechanisms. The contribution of B cells to establishing protective immunity has long been underestimated. Francisella tularensis, including a number of subspecies, provides a suitable model for the study of immune responses against intracellular bacterial pathogens. We previously demonstrated that Francisella infects B cells and activates B-cell subtypes to produce a number of cytokines and express the activation markers. Recently, we documented the early production of natural antibodies as a consequence of Francisella infection in mice. Here, we summarize current knowledge on the innate and acquired humoral immune responses initiated by Francisella infection and their relationships with the immune defense systems.

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A serological and molecular study on Francisella tularensis in rodents from Hamadan province, Western Iran

Cited by 8 publications

References 20 publications

Epidemiology of tularemia in the countries of the WHO Eastern Mediterranean Region (EMRO): A systematic review and meta-analysis

Epidemiology of tularemia in the countries of the WHO Eastern Mediterranean Region (EMRO): A systematic review and meta-analysis

Francisella and tularemia in western Asia, Iran: a systematic review

Francisella and Antibodies

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