A serotonin receptor (Cg5-HTR-1) mediating immune response in oyster Crassostrea gigas

Jia, Yunke; Yang, Bin; Dong, Wenjing; Liu, Zhaoqun; Lv, Zhao; Jia, Zhihao; Qiu, Limei; Wang, Lingling; Song, Linsheng

doi:10.1016/j.dci.2017.12.029

Cited by 16 publications

(10 citation statements)

References 58 publications

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“…Serotonin is of vital importance in neuroendocrine-immune regulation also in bivalves, to protect the host from pathogen infection. A 5-HT1 receptor was identified from C. gigas (Cg5-HTR-1) showing high expression in digestive gland and hemocytes (34). In oyster hemocytes, lipopolysaccharide (LPS) induced the over-expression of Cg5-HTR-1 mRNA, while pretreatment with the receptor blocker methiothepin lead to downregulation of TNFa mRNA and SOD activity, and to increased apoptosis.…”

Section: Pleiotropic Functions Of Serotonin In Bivalvesmentioning

confidence: 99%

“…In oyster hemocytes, lipopolysaccharide (LPS) induced the over-expression of Cg5-HTR-1 mRNA, while pretreatment with the receptor blocker methiothepin lead to downregulation of TNFa mRNA and SOD activity, and to increased apoptosis. The authors concluded that Cg5-HTR-1 plays a crucial role in modulating the immune response to pathogens or in maintaining immune homeostasis (34). Transfection of the Cg5-HTR-1 in HEK293T cells demonstrated that treatment with 5-HT caused inhibition of Adenylate cyclase (AC) and reduction in cAMP levels (34).…”

Section: Pleiotropic Functions Of Serotonin In Bivalvesmentioning

confidence: 99%

“…The authors concluded that Cg5-HTR-1 plays a crucial role in modulating the immune response to pathogens or in maintaining immune homeostasis (34). Transfection of the Cg5-HTR-1 in HEK293T cells demonstrated that treatment with 5-HT caused inhibition of Adenylate cyclase (AC) and reduction in cAMP levels (34).…”

Section: Pleiotropic Functions Of Serotonin In Bivalvesmentioning

confidence: 99%

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Physiological Roles of Serotonin in Bivalves: Possible Interference by Environmental Chemicals Resulting in Neuroendocrine Disruption

et al. 2022

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Contaminants of Emerging Concerns (CECs) are defined as chemicals not commonly monitored in aquatic ecosystems, but with the potential to cause adverse effects on biota. CECs include Endocrine Disrupting Chemicals (EDCs) and Neuro-Endocrine disruptors (NEDs) of vertebrates. However, most invertebrates only rely on neuroendocrine systems to maintain homeostatic processes. Although conserved neuroendocrine components have been characterized in ecologically relevant groups, limited knowledge on invertebrate neuroendocrinology makes it difficult to define EDCs and NEDs in most species. The monoamine serotonin (5-hydroxytryptamine, 5-HT) acts both as a neurotransmitter and as a peripheral hormone in mammals. In molluscs, 5-HT is involved in multiple physiological roles and molecular components of the serotonergic system have been identified. This review is focused on the effects of CECs on the serotonergic system of bivalve molluscs. Bivalves are widespread in all aquatic environments, estuarine and coastal areas in particular, where they are exposed to a variety of chemicals. In bivalves, 5-HT is involved in gametogenesis and spawning, oocyte maturation and sperm motility, regulates heart function, gill ciliary beating, mantle/siphon function, the ‘‘catch’’ state of smooth muscle and immune responses. Components of 5-HT transduction (receptors and signaling pathways) are being identified in several bivalve species. Different CECs have been shown to affect bivalve serotonergic system. This particularly applies to antidepressants, among the most commonly detected human pharmaceuticals in the aquatic environment. In particular, selective serotonin reuptake inhibitors (SSRIs) are frequently detected in seawater and in bivalve tissues. Information available on the effects and mechanisms of action of SSRIs on the serotonergic system of adult bivalves is summarized. Data are also reported on the effects of CECs on development of neuroendocrine pathways of early larval stages, in particular on the effects of model EDCs in the marine mussel Mytilus galloprovincialis. Overall, available data point at the serotonergic system as a sensitive target for neuroendocrine disruption in bivalves. The results contribute drawing Adverse Outcome Pathways (AOPs) for model EDCs and SSRIs in larvae and adults. However, basic research on neuroendocrine signaling is still needed to evaluate the potential impact of neuroendocrine disruptors in key invertebrate groups of aquatic ecosystems.

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Section: Pleiotropic Functions Of Serotonin In Bivalvesmentioning

confidence: 99%

Section: Pleiotropic Functions Of Serotonin In Bivalvesmentioning

confidence: 99%

Section: Pleiotropic Functions Of Serotonin In Bivalvesmentioning

confidence: 99%

See 1 more Smart Citation

Physiological Roles of Serotonin in Bivalves: Possible Interference by Environmental Chemicals Resulting in Neuroendocrine Disruption

et al. 2022

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“…Contents of 5-HT in the nervous system were much higher in bivalves than in other invertebrate species ( Bogdanski et al, 1956 ). Receptors of 5-HT have also been identified in bivalves Mizuhopecten yessoensis ( Tanabe et al, 2010 ) and C. gigas ( Jia et al, 2018 ). These receptors exhibited a high affinity to 5-HT and could relay signals via the mediation of cAMP ( Jia et al, 2018 ).…”

Section: Molecular Components Of the Neuroendocrine System In Marine mentioning

confidence: 99%

“…Receptors of 5-HT have also been identified in bivalves Mizuhopecten yessoensis ( Tanabe et al, 2010 ) and C. gigas ( Jia et al, 2018 ). These receptors exhibited a high affinity to 5-HT and could relay signals via the mediation of cAMP ( Jia et al, 2018 ). Serotonin is an ancient neurotransmitter has been identified as the early origin of the nervous system for both vertebrates and invertebrates ( Berger et al, 2009 ).…”

Section: Molecular Components Of the Neuroendocrine System In Marine mentioning

confidence: 99%

The Neuroendocrine-Immune Regulation in Response to Environmental Stress in Marine Bivalves

Liu

et al. 2018

Front. Physiol.

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Marine bivalves, which include many species worldwide, from intertidal zones to hydrothermal vents and cold seeps, are important components of the ecosystem and biodiversity. In their living habitats, marine bivalves need to cope with a series of harsh environmental stressors, including biotic threats (bacterium, virus, and protozoan) and abiotic threats (temperature, salinity, and pollutants). In order to adapt to these surroundings, marine bivalves have evolved sophisticated stress response mechanisms, in which neuroendocrine regulation plays an important role. The nervous system and hemocyte are pillars of the neuroendocrine system. Various neurotransmitters, hormones, neuropeptides, and cytokines have been also characterized as signal messengers or effectors to regulate humoral and cellular immunity, energy metabolism, shell formation, and larval development in response to a vast array of environmental stressors. In this review substantial consideration will be devoted to outline the vital components of the neuroendocrine system identified in bivalves, as well as its modulation repertoire in response to environmental stressors, thereby illustrating the dramatic adaptation mechanisms of molluscs.

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Biogenic amines in fresh fish and fishery products and emerging control

Arulkumar

Paramithiotis

Paramasivam

2023

Aquaculture and Fisheries

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A serotonin receptor (Cg5-HTR-1) mediating immune response in oyster Crassostrea gigas

Cited by 16 publications

References 58 publications

Physiological Roles of Serotonin in Bivalves: Possible Interference by Environmental Chemicals Resulting in Neuroendocrine Disruption

Physiological Roles of Serotonin in Bivalves: Possible Interference by Environmental Chemicals Resulting in Neuroendocrine Disruption

The Neuroendocrine-Immune Regulation in Response to Environmental Stress in Marine Bivalves

Biogenic amines in fresh fish and fishery products and emerging control

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